Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD : how much retina do you really need to see well?
Havla, Joachim (Ludwig-Maximilians-Universität München)
Pakeerathan, Thivya (Ruhr-Universität Bochum)
Schwake, Carolin (Ruhr-Universität Bochum)
Bennett, Jeffrey L. (University of Colorado Anschutz Medical Campu)
Kleiter, Ingo (Marianne-Strauß-Klinik)
Felipe-Rucián, Ana (Hospital Universitari Vall d'Hebron)
Joachim, Stephanie C. (Ruhr-Universität Bochum)
Lotz-Havla, Amelie S. (Ludwig-Maximilians-Universität München)
Kümpfel, Tania (Ludwig-Maximilians-Universität München)
Krumbholz, Markus (University Hospital of Tübingen (Alemanya))
Wendel, Eva M. (Olgaspital Stuttgart)
Reindl, Markus (Medical University of Innsbruck)
Thiels, Charlotte (Ruhr-University)
Lücke, Thomas (Ruhr-University)
Hellwig, Kerstin (Ruhr-Universität Bochum)
Gold, Ralf (Ruhr-Universität Bochum)
Rostasy, Kevin (University Witten/Herdecke)
Ayzenberg, Ilya (Sechenov First Moscow State Medical University)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	To investigate age-related severity, patterns of retinal structural damage, and functional visual recovery in pediatric and adult cohorts of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) optic neuritis (ON). All MOGAD patients from the 5 participating centers were included. Patients with initial manifestation <18 years were included in the pediatric (MOGAD ped) cohort and patients with ≥18 years in the adult (MOGAD adult) cohort. For patients with MOGAD ON, examinations at least ≥6 months after ON onset were included in the analyses. Using spectral domain optical coherence tomography (SD-OCT), we acquired peripapillary retinal nerve fiber layer thickness (pRNFL) and volumes of combined ganglion cell and inner plexiform layer (GCIPL). High- and 2. 5% low-contrast visual acuity (HCVA, LCVA) and visual-evoked potentials (VEP) were obtained. Twenty MOGAD ped (10. 3±3. 7 years, 30 MOGAD ON eyes) and 39 MOGAD adult (34. 9±11. 6 years, 42 MOGAD ON eyes) patients were included. The average number of ON episodes per ON eye was similar in both groups (1. 8±1. 3 and 2. 0±1. 7). In both pediatric and adult MOGAD, ON led to pronounced neuroaxonal retinal atrophy (pRNFL: 63. 1±18. 7 and 64. 3±22. 9 μm; GCIPL: 0. 42±0. 09 and 0. 44±0. 13 mm 3, respectively) and moderate delay of the VEP latencies (117. 9±10. 7 and 118. 0±14. 5 ms). In contrast, visual acuity was substantially better in children (HCVA: 51. 4±9. 3 vs. 35. 0±20. 6 raw letters, p =0. 001; LCVA: 22. 8±14. 6 vs. 13. 5±16. 4, p =0. 028). Complete visual recovery (HCVA-logMAR 0. 0) occurred in 73. 3% of MOGAD ped and 31% MOGAD adults ON eyes, while 3. 3% and 31% demonstrated moderate to severe (logMAR.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Optical coherence tomography ; Optic neuritis ; Myelin oligodendrocyte glycoprotein IgG ; MOGAD
Publicat a:	Journal of neuroinflammation, Vol. 18 (may 2021) , ISSN 1742-2094

DOI: 10.1186/s12974-021-02160-9
PMID: 34051804

10 p, 1.7 MB

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