Cutaneous Allodynia in Migraine : A Narrative Review
Mínguez-Olaondo, Ane (Clínica Universidad de Navarra)
Quintas, Sonia (Hospital Universitario de la Princesa (Madrid))
Morollón Sánchez-Mateos, Noemí (Institut d'Investigació Biomèdica Sant Pau)
López-Bravo, Alba (Instituto de Investigación Sanitaria de Aragón)
Vila-Pueyo, Marta (Hospital Universitari Vall d'Hebron)
Grozeva, Vesselina (Private Neurology Practice, Sofia)
Belvís, Roberto (Institut d'Investigació Biomèdica Sant Pau)
Santos Lasaosa, Sonia (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Irimia, Pablo (Clínica Universidad de Navarra)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has increased strikingly over the last few decades. Therefore, the clinician treating migraine patients must recognize this common symptom and have up-to-date knowledge of its importance from the pathophysiological, diagnostic, prognostic and therapeutic point of view. We performed a comprehensive narrative review to analyze existing literature regarding CA in migraine, with a special focus on epidemiology, pathophysiology, assessment methods, risk for chronification, diagnosis and management. PubMed and the Cochrane databases were used for the literature search. The prevalence of CA in patients with migraine is approximately 60%. The mechanisms underlying CA in migraine are not completely clarified but include a sensitization phenomenon at different levels of the trigemino-talamo-cortical nociceptive pathway and dysfunction of brainstem and cortical areas that modulate thalamocortical inputs. The gold standard for the assessment of CA is quantitative sensory testing (QST), but the validated Allodynia 12-item questionnaire is preferred in clinical setting. The presence of CA is associated with an increased risk of migraine chronification and has therapeutic implications. CA is a marker of central sensitization in patients with migraine that has been associated with an increased risk of chronification and may influence therapeutic decisions.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Cutaneous allodynia ; Migraine ; Migraine chronification ; Risk factors ; Treatment
Published in:	Frontiers in neurology, Vol. 12 (january 2022) , ISSN 1664-2295

DOI: 10.3389/fneur.2021.831035
PMID: 35153995

10 p, 552.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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