Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis
Hedges, Emily P. (King's College London. Department of Psychosis Studies)
Dickson, Hannah (King's College London. Department of Forensic and Neurodevelopmental Sciences)
Tognin, Stefania (King's College London. Department of Psychosis Studies)
Modinos, Gemma (King's College London. Department of Psychosis Studies)
Antoniades, Mathilde (Icahn School of Medicine. Department of Psychiatry)
van der Gaag, Mark (Parnassia Psychiatric Institute (Nova Zelanda). Department of Psychosis Research)
de Haan, Lieuwe (Arkin Amsterdam)
McGorry, Patrick (University of Melbourne. Centre for Youth Mental Health)
Pantelis, Christos (Melbourne Neuropsychiatry Centre)
Riecher-Rössler, Anita (University of Basel (Suïssa). Faculty of Medicine)
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo (Brasil). Depto Psiquiatria)
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Krebs, Marie-Odile (University of Paris. GHU Psychiatrie et Neurosciences of Paris)
Nordentoft, Merete (Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (Dinamarca))
Ruhrmann, Stephan (University of Cologne (Alemanya). Department of Psychiatry and Psychotherapy)
Sachs, Gabriele (Medical University of Vienna. Department of Psychiatry and Psychotherapy)
Rutten, Bart P. (Maastricht University Medical Centre. Department of Psychiatry and Neuropsychology)
van Os, Jim (Maastricht University Medical Centre. Department of Psychiatry and Neuropsychology)
Valmaggia, Lucia (King's College London)
McGuire, Philip (King's College London. Department of Psychosis Studies)
Kempton, Matthew J. (King's College London. Department of Psychosis Studies)

Data:	2021
Resum:	Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high-risk for psychosis (CHR) compared to healthy populations. As previous studies have shown a relationship between cognition and longer-term outcomes in schizophrenia, the aim of this paper was to explore whether verbal memory and verbal fluency performance predicted outcomes in a large CHR sample recruited as part of the EU-GEI High Risk Study. Participants included 316 CHR individuals, 90. 8% of whom were not currently on antipsychotic medication, and 60 healthy controls. Verbal memory and verbal fluency performance were measured at baseline. At two-year follow-up, CHR individuals were assessed by three different outcome measures, those who did and did not (1) transition to psychosis, (2) experience burdening impairment or disabilities, or (3) remit clinically from CHR status. Individuals with CHR displayed significant verbal memory and verbal fluency deficits at baseline compared to healthy controls (Hedges' g effect size = 0. 24 to 0. 66). There were no significant differences in cognitive performance of those who did and did not transition to psychosis. However, impaired immediate verbal recall predicted both functional disability and non-remission from the CHR state. Results remained significant when analyses were restricted to only include antipsychotic-free CHR participants. These findings may inform the development of early interventions designed to improve cognitive deficits in the early stages of psychosis.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1612 Ministerio de Ciencia e Innovación PSI2017-87512-C2-1-R
Nota:	Altres ajuts: The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community's Seventh Framework Programme. Additional support was provided by a Medical Research Council Fellowship to M Kempton(grant MR/J008915/1). C Pantelis was supported by a NHMRC Senior Principal Research Fellowship (628386 & 1105825), NHMRC Program Grant (ID:1150083)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cognition ; Verbal fluency ; Prodrome ; Transition ; Early intervention
Publicat a:	Schizophrenia Research: Cognition, Vol. 28 (october 2021) , ISSN 2215-0013

DOI: 10.1016/j.scog.2021.100222
PMID: 35242602

8 p, 518.5 KB

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