Home > Articles > Published articles > Low CD4/CD8 ratio is associated with increased morbidity and mortality in late and non-late presenters : |
Date: | 2022 |
Abstract: | To study whether the association between the CD4/CD8 ratio variation over time and the development of clinical outcomes vary in late presenters (CD4 count < 350/µL or AIDS event at enrolment) or advanced presenters (CD4 count < 200/µL or AIDS event at enrolment). We included ART-naïve adults from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) enrolled between January 2004 up to November 2018 and with at least 6 months of follow-up. We used extended Cox proportional hazard models to estimate the hazard ratios (HRs) for the association between CD4/CD8 ratio over time and a composite endpoint of the occurrence of the first AIDS event, first serious non-AIDS event or overall mortality occurring from 6 months after enrolment. HRs in non-late, late and advanced presenters were obtained by including an interaction term between late presentation status and CD4/CD8 ratio over time. Of 10,018 participants, 55. 6% were late presenters and 26. 5% were advanced presenters. Compared with CD4/CD8 ratio > 0. 4, CD4/CD8 ratio ≤ 0. 4 over time was associated with an increased risk of experiencing the composite endpoint in non-late (HR 1. 90; 95%CI 1. 48, 2. 43), late (HR 1. 94; 1. 46, 2. 57) and advanced presenters (HR 1. 72; 1. 26, 2. 34). Similarly, CD4/CD8 ratio ≤ 0. 4 over time was associated with a higher risk of developing an AIDS event (HR 3. 31; 2. 23, 4. 93 in non-late; HR 2. 75; 1. 78, 4. 27 in late and HR 2. 25; 1. 34, 3. 76 in advanced presenters) or serious non-AIDS event (HR 1. 39; 0. 96, 2. 02 in non-late, HR 1. 62; 1. 10, 2. 40 in late and HR 1. 49; 0. 97, 2. 29 in advanced presenters) as well as with a higher risk of overall mortality (HR 1. 49; 0. 92, 2. 41 in non-late, HR 1. 80; 1. 04, 3. 11 in late and HR 1. 61; 0. 92, 2. 83 in advanced presenters) compared to CD4/CD8 > 0. 4, regardless of the late presentation status. A low CD4/CD8 measured over time is associated with increased risk of morbidity and mortality in people living with HIV independently of their late presentation status. These data support the prognostic role of CD4/CD8 over time and can help defining a subgroup of patients who need closer monitoring to avoid comorbidities. The online version contains supplementary material available at 10. 1186/s12879-022-07352-z. |
Grants: | Instituto de Salud Carlos III RD06/006 Instituto de Salud Carlos III RD12/0017/0018 Instituto de Salud Carlos III RD16/0002/0006 |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | Late presentation ; CD4/CD8 ; Clinical outcomes ; AIDS events ; Serious non-AIDS events ; Mortality |
Published in: | BMC Infectious diseases, Vol. 22 (april 2022) , art. 379, ISSN 1471-2334 |
10 p, 795.8 KB |