Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults
Cattaneo, Gabriele (Universitat Autònoma de Barcelona. Departament de Medicina)
Solana-Sánchez, Javier (Universitat Autònoma de Barcelona. Departament de Medicina)
Abellaneda Pérez, Kilian (Universitat Autònoma de Barcelona. Departament de Medicina)
Portellano-Ortiz, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina)
Delgado-Gallén, Selma (Universitat Autònoma de Barcelona. Departament de Medicina)
Alviarez-Schulze, Vanessa (Universitat Autònoma de Barcelona. Departament de Medicina)
Pachón-García, Catherine (Universitat Autònoma de Barcelona. Departament de Medicina)
Zetterberg, Henrik (Hong Kong Center for Neurodegenerative Diseases)
Tormos, Jose Maria (Universitat Autònoma de Barcelona. Departament de Medicina)
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Bartrés-Faz, David (Universitat Autònoma de Barcelona. Departament de Medicina)
Universitat Autònoma de Barcelona. Institut de Neurociències
Institut Germans Trias i Pujol

Data:	2022
Resum:	In recent years, supported by new scientific evidence, the conceptualization of cognitive reserve (CR) has been progressively enriched and now encompasses not only cognitive stimulating activities or educational level, but also lifestyle activities, such as leisure physical activity and socialization. In this context, there is increasing interest in understanding the role of psychological factors in brain health and cognitive functioning. In a previous study, we have found that these factors mediated the relationship between CR and self-reported cognitive functioning. In this study, we have confirmed an association between two important constructs included in the psychological wellbeing and salutogenic models, "purpose in life" and "sense of coherence," CR, as assessed using a questionnaire, and cognitive functioning, as evaluated using a comprehensive neuropsychological battery. Results from 888 middle-aged healthy participants from the Barcelona Brain Health Initiative indicate that both sense of coherence (SoC) and CR were positively associated with verbal memory, reasoning and attention, working memory, and global cognition. Moreover, the relation between CR and cognitive functioning in the different domains is partially mediated by SoC. When we controlled for brain integrity, introducing into the model neurofilament light chain measures, the mediator role of SoC was confirmed for reasoning and attention and global cognition. However, purpose in life was not associated with cognitive functioning. These results reveal the central role of the SoC construct, which mediates the association between classic CR estimates and cognitive functions, potentially representing a modifiable target for interventions that aim to promote brain health.
Ajuts:	"la Caixa" Foundation LCF/PR/PR16/11110004 Agencia Estatal de Investigación RTI2018-095181-B-C21 Agència de Gestió d'Ajuts Universitaris i de Recerca 2018PROD00172 Fundació la Marató de TV3 201735.10 European Commission 777107
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Sense of coherence ; Purpose in life ; Cognition ; Cognitive reserve ; Brain health
Publicat a:	Frontiers in psychology, Vol. 13 (march 2022) , ISSN 1664-1078

DOI: 10.3389/fpsyg.2022.835415
PMID: 35418913

9 p, 740.8 KB

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