guest ::
| Home > Articles > Published articles > Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing |
| Home > Articles > Published articles > Prediabetes Is Associated with Increased Prevalence of Sleep-Disordered Breathing |
(Universitat de Lleida) (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) (Universitat de Lleida) (Universitat de Lleida) (Red de Investigación Renal, Instituto de Salud Carlos III (RedinRen-ISCIII), 28029 Madrid, Spain) (Red de Investigación Renal, Instituto de Salud Carlos III (RedinRen-ISCIII), 28029 Madrid, Spain) (Institut de Recerca Biomèdica de Lleida) (Red de Investigación Renal (REDINREN)) (Lleida Research Support Unit, Jordi Gol i Gurina University Institute for Research in Primary Health Care (IDIAPJGol), 25007 Lleida, Spain) (Institut de Recerca Biomèdica de Lleida) (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) (Universitat Autònoma de Barcelona) (Universitat Autònoma de Barcelona) (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
| Date: | 2022 |
| Abstract: | Type 2 diabetes leads to severe nocturnal hypoxemia, with an increase in apnea events and daytime sleepiness. Hence, we assessed sleep breathing parameters in the prediabetes stage. A cross-sectional study conducted on 966 middle-aged subjects without known pulmonary disease (311 patients with prediabetes and 655 controls with normal glucose metabolism) was conducted. Prediabetes was defined by glycated hemoglobin (HbA1c), and a nonattended overnight home sleep study was performed. Participants with prediabetes (n = 311) displayed a higher apnea-hypopnea index (AHI: 12. 7 (6. 1;24. 3) vs. 9. 5 (4. 2;19. 6) events/h, p < 0. 001) and hypopnea index (HI: 8. 4 (4. 0;14. 9) vs. 6. 0 (2. 7;12. 6) events/h, p < 0. 001) than controls, without differences in the apnea index. Altogether, the prevalence of obstructive sleep apnea was higher in subjects with prediabetes than in controls (78. 1 vs. 69. 9%, p = 0. 007). Additionally, subjects with prediabetes presented impaired measurements of the median and minimum nocturnal oxygen saturation, the percentage of time spent with oxygen saturations below 90%, and the 4% oxygen desaturation index in comparison with individuals without prediabetes (p < 0. 001 for all). After adjusting for age, sex, and the presence of obesity, HbA1c correlated with the HI in the entire population (r = 0. 141, p < 0. 001), and the presence of prediabetes was independently associated with the AHI (B = 2. 20 (0. 10 to 4. 31), p = 0. 040) as well as the HI (B = 1. 87 (0. 61 to 3. 14), p = 0. 004) in the multiple linear regression model. We conclude that prediabetes is an independent risk factor for an increased AHI after adjusting for age, sex, and obesity. The enhanced AHI is mainly associated with increments in the hypopnea events. |
| Grants: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-696 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT002160025 Ministerio de Economía y Competitividad PI12/00803 Ministerio de Economía y Competitividad PI15/00260 Instituto de Salud Carlos III PI18/00964 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Apnea ; Glycated hemoglobin ; Hypopnea ; Prediabetes ; Obstructive sleep apnea |
| Published in: | Journal of clinical medicine, Vol. 11 (march 2022) , ISSN 2077-0383 |
