Risk factors for nosocomial bloodstream infections in COVID-19 affected patients : protocol for a case-control study
Codina-Jiménez, Carla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Marin, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Álvarez, Marlene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Quesada, Maria Dolores (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Rodríguez-Ponga, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Valls, Ester (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Quiñones Ribas, Carles (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Nosocomial bloodstream infection (nBSI) is an important clinical concern among COVID-19 hospitalised patients. It can cause sepsis and septic shock leading to high morbidity, mortality, and the emergence of antibiotic resistance. The aim of this case-control study is to identify the risk factors associated with the nBSI development in COVID-19 hospitalised patients and its incidence. A retrospective case-control study will be performed. Cases will include nBSI episodes of adult patients (≥18 years) admitted to Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, from April to December 2020 with a diagnosis of SARS-CoV-2 pneumonia. Patients transferred from other hospitals will be excluded. Controls will include hospitalisation episodes of COVID-19 patients without nBSI. We will recruit a minimum of 74 nBSI episodes (cases) and 74 controls (according to sample size calculation). We will collect data on sociodemographics, clinical status at admission, hospital admission, in-hospital mortality, and exposure data (use of antivirals, glucocorticoids or immunomodulatory agents, length of hospitalisation, and use of medical devices such as intravenous catheters). A bivariate and a subsequent multivariate regression analysis will be performed to assess the independent effect of the associated risk factors after adjusting for confounders. The nBSI incidence rate will be estimated according to the number of nBSI episodes in admitted COVID-19 patients among the total person-month of follow-up. The protocol of this study was approved by the Ethical Committee for Drug Investigation of the Hospital Universitari Germans Trias i Pujol. The results of this case-control study will be published in a peer reviewed journal.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Case-control studies ; Critical care ; COVID-19 ; Drug-related side effects and adverse reactions ; Pharmacy service ; Hospital
Published in:	European Journal of Hospital Pharmacy, Vol. 29 (august 2021) , p. e2-e5, ISSN 2047-9964

DOI: 10.1136/ejhpharm-2021-002776
PMID: 34400550

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles