Magnetic Mesoporous Silica Nanorods Loaded with Ceria and Functionalized with Fluorophores for Multimodal Imaging
Grzelak, Jan (Institut de Ciència de Materials de Barcelona)
Gázquez, Jaume (Institut de Ciència de Materials de Barcelona)
Grayston, Alba (Hospital Universitari Vall d'Hebron)
Teles, Mariana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Herranz, Fernando (Consejo Superior de Investigaciones Científicas (Espanya))
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron)
Roig i Serra, Anna (Institut de Ciència de Materials de Barcelona)
Gich García, Martí (Institut de Ciència de Materials de Barcelona)

Date:	2022
Abstract:	Multifunctional magnetic nanocomposites based on mesoporous silica have a wide range of potential applications in catalysis, biomedicine, or sensing. Such particles combine responsiveness to external magnetic fields with other functionalities endowed by the agents loaded inside the pores or conjugated to the particle surface. Different applications might benefit from specific particle morphologies. In the case of biomedical applications, mesoporous silica nanospheres have been extensively studied while nanorods, with a more challenging preparation, have attracted much less attention despite the positive impact on the therapeutic performance shown by seminal studies. Here, we report on a sol-gel synthesis of mesoporous rodlike silica particles of two distinct lengths (1. 4 and 0. 9 μm) and aspect ratios (4. 7 and 2. 2) using Pluronic P123 as a structure-directing template and rendering ∼1 g of rods per batch. Iron oxide nanoparticles have been synthesized within the pores yielding maghemite (γ-FeO) nanocrystals of elongated shape (∼7 nm × 5 nm) with a [110] preferential orientation along the rod axis and a superparamagnetic character. The performance of the rods as T-weighted MRI contrast agents has also been confirmed. In a subsequent step, the mesoporous silica rods were loaded with a cerium compound and their surface was functionalized with fluorophores (fluorescamine and Cyanine5) emitting at λ = 525 and 730 nm, respectively, thus highlighting the possibility of multiple imaging modalities. The biocompatibility of the rods was evaluated in vitro in a zebrafish (Danio rerio) liver cell line (ZFL), with results showing that neither long nor short rods with magnetic particles caused cytotoxicity in ZFL cells for concentrations up to 50 μg/ml. We advocate that such nanocomposites can find applications in medical imaging and therapy, where the influence of shape on performance can be also assessed.
Grants:	Ministerio de Ciencia e Innovación RYC2019-026841-I Agencia Estatal de Investigación RTI2018-096273-B-I00 Ministerio de Ciencia e Innovación CEX2019-000917-S Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-765
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Mesoporous silica rods ; Superparamagnetic nanoparticles ; Magnetic resonance imaging ; Fluorescence imaging ; Multimodal nanoparticles ; Anisotropic nanoparticles
Published in:	ACS applied nano materials, Vol. 5 (02 2022) , p. 2113-2125, ISSN 2574-0970

DOI: 10.1021/acsanm.1c03837
PMID: 35252779

13 p, 10.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles