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Página principal > Artículos > Artículos publicados > Outstanding improvement of the advanced lipoprotein profile in subjects with new-onset type 1 diabetes mellitus after achieving optimal glycemic control |
Fecha: | 2021 |
Resumen: | Aims: The impact of glycemic optimization on lipoprotein subfraction parameters in apparently normolipidemic subjects with new-onset type 1 diabetes mellitus (T1D) was examined. Methods: We evaluated the serum lipid and advanced lipoprotein profiles in twenty subjects at onset of T1D and twenty non-diabetic controls by laboratory methods and 1H NMR spectroscopy shortly after diabetes diagnosis (baseline), and after achieving optimal glycemic control (HbA1c ≤ 7. 0%). Results: Advanced lipoprotein analysis revealed a significant reduction from baseline in serum concentrations of triglycerides (TG), cholesterol (C), and apolipoprotein (Apo)B-containing lipoproteins of treated subjects (VLDL-TG: −21%, IDL-TG: −30%, LDL-TG: −34%, LDL-TG: −36%, P < 0. 05; VLDL-C: -23%, IDL-C: −44%, LDL-C: −16%; p < 0. 05). Decreased VLDL and LDL lipids were mainly attributed to concomitant reductions in the concentration of medium-sized VLDL (-36%) and medium-sized LDL (-31%) and, to a lesser extent, to large-sized LDL (-14%). Notably, proatherogenic IDL characteristics and related surrogates of atherogenicity were resolved upon achievement of optimal glycemic status. Moreover, the concentration of HDL-TG was also reduced (−18%) at follow-up. Conclusions: Our data showed that the achievement of optimal glycemic control after T1D onset corrected hidden derangements in ApoB-containing lipoproteins (particularly IDL) and HDL-TG that are related to higher cardiovascular risk in poorly controlled T1D. |
Ayudas: | Instituto de Salud Carlos III PI15-0625 Instituto de Salud Carlos III PI17-01362 Instituto de Salud Carlos III PI17-00232 Instituto de Salud Carlos III CPII18-00004 |
Nota: | Altres ajuts: Fundació La Marató de TV3 (303/C/2016)(201602.30.31) |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió de l'autor |
Materia: | Diabetic dyslipidemia ; Nuclear magnetic resonance (1H NMR) spectroscopy ; Cardiovascular risk ; Lipoprotein remnants ; Type 1 diabetes |
Publicado en: | Diabetes research and clinical practice, Vol. 182 (december 2021) , p. 109145, ISSN 1872-8227 |
Versió de l'autor 18 p, 506.2 KB |