Addressing nanomaterial immunosafety by evaluating innate immunity across living species
Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols))
Alijagic, Andi (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo))
Auguste, Manon (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita)
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia)
Ferrari, Eleonora (ZMBP Eberhard-Karls University Tübingen. Center for Plant Molecular Biology)
Hernadi, Szabolcs (Cardiff University. School of Biosciences)
Mayall, Craig (University of Liubljana. Department of Biology)
Michelini, Sara (Paris-Lodron-University Salzburg. Department of Biosciences)
Navarro Pacheco, Natividad I. (Czech Academy of Sciences. Institute of Microbiology)
Prinelli, Alessandra (AvantiCell Science Ltd)
Swart, Elmer (UK Centre for Ecology and Hydrology)
Swartzwelter, Benjamin J. (Istituto di Biochimica e Biologia Cellulare (Nàpols))
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia)
Canesi, Laura (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita)
Drobne, Damjana (University of Liubljana. Department of Biology)
Duschl, Albert (Paris-Lodron-University Salzburg. Department of Biosciences)
Ewart, Marie-Ann (AvantiCell Science Ltd)
Horejs-Hoeck, Jutta (Paris-Lodron-University Salzburg. Department of Biosciences)
Italiani, Paola (Istituto di Biochimica e Biologia Cellulare (Nàpols))
Kemmerling, Birgit (Center for Plant Molecular Biology - ZMBP. Eberhard-Karls University Tübingen)
Kille, Peter (Cardiff University. School of Biosciences)
Prochazkova, Petra (Czech Academy of Sciences. Institute of Microbiology)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Spurgeon, David J. (UK Centre for Ecology and Hydrology)
Svendsen, Claus (UK Centre for Ecology and Hydrology)
Wilde, Colin J. (AvantiCell Science Ltd)
Pinsino, Annalisa (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo))

Data:	2020
Resum:	The interaction of a living organism with external foreign agents is a central issue for its survival and adaptation to the environment. Nanosafety should be considered within this perspective, and it should be examined that how different organisms interact with engineered nanomaterials (NM) by either mounting a defensive response or by physiologically adapting to them. Herein, the interaction of NM with one of the major biological systems deputed to recognition of and response to foreign challenges, i. e. , the immune system, is specifically addressed. The main focus is innate immunity, the only type of immunity in plants, invertebrates, and lower vertebrates, and that coexists with adaptive immunity in higher vertebrates. Because of their presence in the majority of eukaryotic living organisms, innate immune responses can be viewed in a comparative context. In the majority of cases, the interaction of NM with living organisms results in innate immune reactions that eliminate the possible danger with mechanisms that do not lead to damage. While in some cases such interaction may lead to pathological consequences, in some other cases beneficial effects can be identified.
Ajuts:	European Commission 812661 European Commission 671881 Ministerio de Economía y Competitividad SEV-2017-0706 Ministerio de Economía y Competitividad RYC-2012-10991 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1431
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Evolution ; Immunosafety ; Innate immunity ; Nanomaterials
Publicat a:	Small, Vol. 16, issue 21 (May 2020) , art. 2000598, ISSN 1613-6829

DOI: 10.1002/smll.202000598

26 p, 2.5 MB

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