Integrated devices for non-invasive diagnostics
Ates, Hatice Ceren (Freiburg Centre for Interactive Materials and Bioinspired Technology)
Brunauer, Anna (University of Freiburg. Department of Microsystems Engineering)
von Stetten, Felix (Hahn-Schickard)
Urban, Gerald Anton (University of Freiburg. Department of Microsystems Engineering)
Güder, Firat (Imperial College London. Department of Bioengineering)
Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)
Früh, Susanna Maria (Hahn-Schickard)
Dincer, Can (University of Freiburg. Department of Microsystems Engineering)

Data:	2021
Resum:	"Sample-in-answer-out" type integrated diagnostic devices have been widely recognized as the ultimate solution to simplify testing across healthcare systems. Such systems are equipped with advanced fluidic, mechanical, chemical, biological, and electronic components to handle patient samples without any manual steps therefore have the potential to accelerate intervention and improve patient outcomes. In this regard, the combination of integrated devices and non-invasive sampling has gained a substantial interest to further improve the comfort and safety of patients. In this Review, the pioneering developments in integrated diagnostics are covered and their potential in non-invasive sampling is discussed. The key properties of possible sample types are highlighted by addressing their relevance for the clinical practice. Last, the factors affecting the transition of integrated devices from academia to the market are identified by analyzing the technology readiness levels of selected examples and alternative remedies are explored to increase the rate of survival during this transition.
Ajuts:	Agencia Estatal de Investigación SEV-2017-0706 Agencia Estatal de Investigación MAT2017-87202-P
Nota:	Altres ajuts: A.M. thanks funding by the CERCA programme/Generalitat de Catalunya.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Integrated sensors ; Microfluidics ; Non-invasive diagnostics ; Point-of-care testing ; Wearables
Publicat a:	Advanced functional materials, Vol. 31, issue 15 (April 2021) , art. 2010388, ISSN 1616-3028

DOI: 10.1002/adfm.202010388

18 p, 5.3 MB

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