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Pàgina inicial > Articles > Articles publicats > Sleep/wake cycle alterations as a cause of neurodegenerative diseases : |
Data: | 2021 |
Resum: | Sleep and/or wake cycle alterations are common in neurodegenerative diseases (ND). Our aim was to determine whether there is a causal relationship between sleep and/or wake cycle patterns and ND (Parkinson's disease (PD) age at onset (AAO), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS)) using two-sample Mendelian Randomization (MR). We selected 12 sleep traits with available Genome-Wide Association Study (GWAS) to evaluate their causal relationship with the ND risk through Inverse-Variance Weighted regression as main analysis. We used as outcome the latest ND GWAS with available summary-statistics: PD-AAO (N = 17,996), AD (N = 21,235) and ALS (N = 40,136). MR results pointed to a causal effect of subjective and objective-measured morning chronotype on later PD-AAO (95%CI:0. 33-1. 81, p = 8. 47×10 and 95%CI:-7. 28 to -4. 44, p = 5. 87×10, respectively). Sleep efficiency was causally associated with a decreased AD risk (95%CI:-20. 408 to -0. 66, p = 0. 04) and daytime sleepiness with an increased ALS risk (95%CI:0. 15 to 1. 61, p = 0. 01). Our study suggests that sleep and/or wake patterns have causal relationship with ND. Given that sleep and/or wake patterns are modifiable risk factors, sleep interventions should be investigated as a potential treatment in PD-AAO, AD and ALS. |
Ajuts: | Instituto de Salud Carlos III PI17/02089 Instituto de Salud Carlos III RD16/0019/0002 Instituto de Salud Carlos III RD16/0019/0010 Instituto de Salud Carlos III RD16/0019/0011 Instituto de Salud Carlos III RD16/0019/0021 Instituto de Salud Carlos III CD20/00043 Instituto de Salud Carlos III CM18/00198 Agència de Gestió d'Ajuts Universitaris i de Recerca FI_DGR 2020 Agència de Gestió d'Ajuts Universitaris i de Recerca 2020FI_B1 00157 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Mendelian randomization ; Parkinson's disease ; Sleep and/or wake cycle ; Alzheimer's disease ; Neurodegenerative disease |
Publicat a: | Neurobiology of Aging, Vol. 106 (october 2021) , p. 320.e1-320.e12, ISSN 1558-1497 |
12 p, 2.0 MB |