Outcome measures and biomarkers in chronic inflammatory demyelinating polyradiculoneuropathy : from research to clinical practice
Allen, J.A. (Department of Neurology. University of Minnesota)
Eftimov, Filip (Amsterdam University Medical Center (UMC))
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau)

Data:	2021
Resum:	Introduction: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated syndrome characterized clinically by weakness and/or numbness that evolves over 2 months or more. The heterogeneity of clinical features necessitates an individualized approach to disease monitoring that takes lessons learned from clinical trials and applies them to clinical practice. Areas covered: This review discusses the importance of clinimetrics and biomarkers in CIDP diagnosis and disease monitoring. Highlighted are the challenges of defining responses to immunotherapy, the usefulness, and limitations of utilizing evidence-based clinical outcome measures during routine clinical care, and the evolving understanding of how diagnostic and disease activity biomarkers may reshape our treatment and disease monitoring paradigms. Expert opinion: Although disability and impairment outcome measures are commonly used in CIDP to indicate disease status, the nonspecific nature of these metrics limits the ability to attribute a change in any given metric to a change in CIDP. This interpretive challenge may be magnified by inconsistencies in the direction of change as well as a strong placebo effect. There is a need to improve our understanding of minimally important changes in existing outcome measures as a means to personalize treatment and to better assess disease activity status with biomarker discovery.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	Chronic inflammatory demyelinating ; Polyradiculoneuropathy ; Clinical outcome measures ; Biomarkers ; Diagnosis ; Disease activity ; Disability ; Impairment ; Minimal clinically important difference
Publicat a:	Expert Review of Neurotherapeutics, Vol. 21 Núm. 7 (2021) , p. 805-816, ISSN 1744-8360

DOI: 10.1080/14737175.2021.1944104
PMID: 34130574

13 p, 2.1 MB

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