Sleep disorders in adults with down syndrome
Giménez, Sandra (Institut d'Investigació Biomèdica Sant Pau)
Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau)
Blessing, Esther (NYU Langone Health (Nova York, Estats Units d'Amèrica). Department of Psychiatry)
Osorio, Ricardo M. (NYU Langone Health (Nova York, Estats Units d'Amèrica). Department of Psychiatry)
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often overlooked due to a lack of awareness by families and physicians and the absence of specific clinical sleep guidelines. Untreated sleep disorders have a negative impact on physical and mental health, behavior, and cognitive performance. Growing evidence suggests that sleep disruption may also accelerate the progression to symptomatic Alzheimer's disease (AD) in this population. It is therefore imperative to have a better understanding of the sleep disorders associated with DS in order to treat them, and in doing so, improve cognition and quality of life, and prevent related comorbidities. This paper reviews the current knowledge of the main sleep disorders in adults with DS, including evaluation and management. It highlights the existing gaps in knowledge and discusses future directions to achieve earlier diagnosis and better treatment of sleep disorders most frequently found in this population.
Grants:	Ministerio de Economía y Competitividad PI14/01126 Instituto de Salud Carlos III PI17/01019 Instituto de Salud Carlos III PI20/00836
Note:	Altres ajuts: National Institutes of Health (NIH grants 1R01AG056850-01A1; R21AG056974; R01AG061566)
Note:	Altres ajuts: Jérôme Lejeune Foundation JLF1801
Note:	Altres ajuts: Fundación Tatiana Pérez de Guzmán el Bueno
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Down syndrome ; Aging ; Sleep disorders ; Obstructive sleep apnea ; Insomnia ; Alzheimer's disease
Published in:	Journal of clinical medicine, Vol. 10 Núm. 14 (february 2021) , p. 3012, ISSN 2077-0383

DOI: 10.3390/jcm10143012
PMID: 34300177

16 p, 1.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles