Venetoclax in relapsed/refractory blastic plasmacytoid dendritic cell neoplasm with central nervous system involvement : a case report and review of the literature
Albiol, Nil (Institut d'Investigació Biomèdica Sant Pau)
Novelli, Silvana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mozos, Ana (Institut d'Investigació Biomèdica Sant Pau)
Pratcorona, Marta (Institut d'Investigació Biomèdica Sant Pau)
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau)
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau)

Date:	2021
Abstract:	Background: We describe a patient with blastic plasmacytoid dendritic cell neoplasm with central nervous system involvement and the outcome of venetoclax use in this setting. Case presentation: A 54-year-old Caucasian male was referred to the Haematology Unit with an enlarged inguinal lymph node which was diagnostic of a blastic plasmacytoid dendritic cell neoplasm. The staging revealed disseminated disease (skin, visceral, lymph nodes, and bone marrow). He received chemotherapy with an acute myeloid leukaemia-like regime. Afterwards, he underwent allogeneic haematopoietic stem cell transplantation, though it was not successful, showing a relapse 14 months later with hepatic and central nervous system dissemination. Intrathecal chemotherapy was administered, and venetoclax (anti-bcl2 agent) was started in an off-label indication based on most recent literature. The disease halted its course for 3 months. In the end, the patient's disease progressed and so he succumbed due to infectious complications. Conclusions: Venetoclax monotherapy seems not enough to control the disease progression under CNS involvement and other treatments should be investigated.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Blastic plasmacytoid dendritic cell neoplasm ; Bcl-2 ; Venetoclax ; BPDCN
Published in:	Journal of Medical Case Reports, Vol. 15 Núm. 1 (december 2021) , p. 326, ISSN 1752-1947

DOI: 10.1186/s13256-021-02939-7
PMID: 34172079

7 p, 1.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles