Organ-on-a-chip technology : A novel approach to investigate cardiovascular diseases
Paloschi, V. (German Center for Cardiovascular Research (DZHK). Partner Site Munich Heart Alliance)
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau)
Middelkamp, H. (BIOS/Lab on A Chip. University of Twente)
Vivas, Aisen (Applied Stem Cell Technologies. University of Twente)
Johansson, S.. (Department of Materials Science and Engineering,Science for Life Laboratory. Uppsala University)
Van Der Meer, A. (Applied Stem Cell Technologies. University of Twente)
Tenje, M. (Department of Materials Science and Engineering,Science for Life Laboratory. Uppsala University)
Maegdefessel, L. (Karolinska Institutet (Estocolm, Suècia). Department of Medicine)

Data:	2021
Resum:	The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture experiments by allowing a better mimicry of human physiology and pathophysiology that has consequently led researchers to gain more meaningful insights into disease mechanisms. Several models of hearts-on-chips and vessels-on-chips have been demonstrated to recapitulate fundamental aspects of the human cardiovascular system in the recent past. These 2D and 3D systems include synchronized beating cardiomyocytes in hearts-on-chips and vessels-on-chips with layer-based structures and the inclusion of physiological and pathological shear stress conditions. The opportunities to discover novel targets and to perform drug testing with chip-based platforms have substantially enhanced, thanks to the utilization of patient-derived cells and precise control of their microenvironment. These organ models will provide an important asset for future approaches to personalized cardiovascular medicine and improved patient care. However, certain technical and biological challenges remain, making the global utilization of OoCs to tackle unanswered questions in cardiovascular science still rather challenging. This review article aims to introduce and summarize published work on hearts- and vessels-on chips but also to provide an outlook and perspective on how these advanced in vitro systems can be used to tailor disease models with patient-specific characteristics.
Ajuts:	European Commission. Horizon 2020 679777
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Organs-on-chips ; Cell culture ; Cardiovascular ; Heart ; Personalized medicine
Publicat a:	Cardiovascular research, Vol. 117 Núm. 14 (january 2021) , p. 2742-2754, ISSN 1755-3245

DOI: 10.1093/cvr/cvab088
PMID: 33729461

13 p, 1.0 MB

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