Progress in cardiac research : From rebooting cardiac regeneration to a complete cell atlas of the heart
Davidson, Sean M (Hatter Cardiovascular Institute. University College London)
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau)
Bollini, S. (Department of Experimental Medicine (DIMES). University of Genova)
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Duncker, D.J. (Division of Experimental Cardiology. Department of Cardiology. Erasmus University Medical Center)
Evans, P.C. (Department of Infection. Immunity and Cardiovascular Disease and Insigneo Institute. University of Sheffield)
Guzik, T. (Department of Medicine. Jagiellonian University. Collegium Medicum)
Hoefer, I.E. (Central Diagnostic Laboratory. University Medical Center Utrecht)
Waltenberger, J. (Department of Cardiovascular Medicine. Medical Faculty. University of Muenster)
Wojta, J. (Department of Internal Medicine Ii. Medical University of Vienna)
Weber, C. (Cardiovascular Research Institute Maastricht (CARIM). Department of Biochemistry. Maastricht University)

Data:	2021
Resum:	We review some of the important discoveries and advances made in basic and translational cardiac research in 2020. For example, in the field of myocardial infarction (MI), new aspects of autophagy and the importance of eosinophils were described. Novel approaches, such as a glycocalyx mimetic, were used to improve cardiac recovery following MI. The strategy of 3D bio-printing was shown to allow the fabrication of a chambered cardiac organoid. The benefit of combining tissue engineering with paracrine therapy to heal injured myocardium is discussed. We highlight the importance of cell-to-cell communication, in particular, the relevance of extracellular vesicles, such as exosomes, which transport proteins, lipids, non-coding RNAs, and mRNAs and actively contribute to angiogenesis and myocardial regeneration. In this rapidly growing field, new strategies were developed to stimulate the release of reparative exosomes in ischaemic myocardium. Single-cell sequencing technology is causing a revolution in the study of transcriptional expression at cellular resolution, revealing unanticipated heterogeneity within cardiomyocytes, pericytes and fibroblasts, and revealing a unique subpopulation of cardiac fibroblasts. Several studies demonstrated that exosome- and non-coding RNA-mediated approaches can enhance human induced pluripotent stem cell (iPSC) viability and differentiation into mature cardiomyocytes. Important details of the mitochondrial Ca2+ uniporter and its relevance were elucidated. Novel aspects of cancer therapeutic-induced cardiotoxicity were described, such as the novel circular RNA circITCH, which may lead to novel treatments. Finally, we provide some insights into the effects of SARS-CoV-2 on the heart.
Ajuts:	Ministerio de Ciencia e Innovación PGC2018-094025-B-I00 Instituto de Salud Carlos III PI19/01687 European Research Council CoG-2016-InflammaTENSION
Nota:	Altres ajuts: Hatter Cardiovascular Institute; British Heart Foundation (PG/18/44/33790, RG/19/10/34506); Fondo Europeo de Desarrollo Regional (FEDER) 'Una Manera de Hacer Europa'; University of Genova ('Curiosity Driven' grant); Dutch Heart Foundation (CVON2014-RECONNECT, CVON2017-ARENA PRIME).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	Cardiac ; Myocardial infarction ; Myocardial injury ; Heart failure ; Non-coding RNA ; Cardiomyocyte division ; Induce pluripotent stem cells ; Cardiotoxicity ; Single-cell RNA sequencings ; COVID-19
Publicat a:	Cardiovascular research, Vol. 117 Núm. 10 (january 2021) , p. 2161-2174, ISSN 1755-3245

DOI: 10.1093/cvr/cvab200
PMID: 34114614

14 p, 1.2 MB

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