Modern Management Options for Ph+ ALL
Ribera, Jose-Maria (Universitat Autònoma de Barcelona. Departament de Medicina)
Chiaretti, Sabina (Università degli Studi di Roma "La Sapienza")

Data:	2022
Resum:	Impressive advances have been achieved in the management of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) since the initial concurrent use of imatinib and standard chemotherapy. The attenuation of chemotherapy has proven to be equally effective and less toxic, the use of third generation TKI upfront has improved the frequency of complete molecular response and the survival rate, and the combination of tyrosine kinase inhibitors with immunotherapy has further increased the rate of molecular response to 70-80% after consolidation, which has been translated into a survival rate of 75-90% in recent trials. As a result of these improvements, the role of allogeneic hematopoietic stem cell transplantation is being redefined. The methodology of measurable residual disease assessment and the detection of ABL1 mutations are also improving and will contribute to a more precise selection of the treatment for newly diagnosed and relapsed or refractory (R/R) patients. Finally, new compounds combined with immunotherapeutic approaches, including cellular therapy, are being used as rescue therapy and will hopefully be included in first line therapy in the near future. This article will review and update the modern management of patients with Ph+ ALL.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acute lymphoblastic leukemia ; Philadelphia chromosome ; Modern management
Publicat a:	Cancers, Vol. 14 Núm. 19 (september 2022) , p. 4554, ISSN 2072-6694

DOI: 10.3390/cancers14194554
PMID: 36230478

11 p, 617.6 KB

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