Clinical and therapeutic implications of epstein-barr virus in hiv-related lymphomas
Verdu-Bou, Miriam (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Tapia, Gustavo (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Hernandez-Rodriguez, Agueda (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Navarro Ferrando, José Tomás (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2021
Abstract:	The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the prevalence of Epstein-Barr virus (EBV) is high. It has been shown that EBV is involved in different lymphomagenic mechanisms mediated by some of its proteins, contributing to the development of different lymphoma subtypes. Additionally, cooperation between both HIV and EBV can lead to the proliferation of aberrant B-cells, thereby being an additional lymphomagenic mechanism in EBV-associated HRL. Despite the close relationship between EBV and HRL, the impact of EBV on clinical aspects has not been extensively studied. These lymphomas are treated with the same therapeutic regimens as the general population in combination with cART. Nevertheless, new therapeutic strategies targeting EBV are promising for these lymphomas. In this article, the different types of HRL are extensively reviewed, focusing on the influence of EBV on the epidemiology, pathogenesis, clinical presentation, and pathological characteristics of each lymphoma subtype. Moreover, novel therapies targeting EBV and future strategies to treat HRL harboring EBV are discussed.
Grants:	Instituto de Salud Carlos III PI19/01588
Note:	Altres ajuts: Gilead Sciences (GLD19/00121)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Epstein-Barr virus ; Human immunodeficiency virus ; HIV-related lymphomas
Published in:	Cancers, Vol. 13 Núm. 21 (november 2021) , p. 5534, ISSN 2072-6694

DOI: 10.3390/cancers13215534
PMID: 34771697

27 p, 1.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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Articles > Published articles