Experimental and Bioinformatic Approaches to Studying DNA Methylation in Cancer
Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	DNA methylation is an essential epigenetic mark. Alterations of normal DNA methylation are a defining feature of cancer. Here, we review experimental and bioinformatic approaches to showcase the breadth and depth of information that this epigenetic mark provides for cancer research. First, we describe classical approaches for interrogating bulk DNA from cell populations as well as more recently developed approaches for single cells and multi-Omics. Second, we focus on the computational analysis from primary data processing to the identification of unique methylation signatures. Additionally, we discuss challenges such as sparse data and cellular heterogeneity. https://doi. org/10. 13039/5011000110335https://doi. org/10. 13039/5011000110333https://doi. org/10. 13039/5011000110336https://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033_https://doi. org/10. 13039/501100011033_https://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033 $h ttps://doi. org/10. 13039/501100011033ahttps://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033Ahttps://doi. org/10. 13039/501100011033ghttps://doi. org/10. 13039/501100011033ehttps://doi. org/10. 13039/501100011033nhttps://doi. org/10. 13039/501100011033chttps://doi. org/10. 13039/501100011033ihttps://doi. org/10. 13039/501100011033ahttps://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033Ehttps://doi. org/10. 13039/501100011033shttps://doi. org/10. 13039/501100011033thttps://doi. org/10. 13039/501100011033ahttps://doi. org/10. 13039/501100011033thttps://doi. org/10. 13039/501100011033ahttps://doi. org/10. 13039/501100011033lhttps://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033dhttps://doi. org/10. 13039/501100011033ehttps://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033Ihttps://doi. org/10. 13039/501100011033nhttps://doi. org/10. 13039/501100011033vhttps://doi. org/10. 13039/501100011033ehttps://doi. org/10. 13039/501100011033shttps://doi. org/10. 13039/501100011033thttps://doi. org/10. 13039/501100011033ihttps://doi. org/10. 13039/501100011033ghttps://doi. org/10. 13039/501100011033ahttps://doi. org/10. 13039/501100011033chttps://doi. org/10. 13039/501100011033ihttps://doi. org/10. 13039/501100011033óhttps://doi. org/10. 13039/501100011033nhttps://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033 $h ttps://doi. org/10. 13039/501100011033dhttps://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033 $h ttps://doi. org/10. 13039/501100011033fhttps://doi. org/10. 13039/501100011033 https://doi. org/10. 13039/501100011033Rhttps://doi. org/10. 13039/501100011033Thttps://doi. org/10. 13039/501100011033Ihttps://doi. org/10. 13039/5011000110332https://doi. org/10. 13039/5011000110330https://doi. org/10. 13039/5011000110331https://doi. org/10. 13039/5011000110338https://doi. org/10. 13039/501100011033-https://doi. org/10. 13039/5011000110330https://doi. org/10. 13039/5011000110339https://doi. org/10. 13039/5011000110334https://doi. org/10. 13039/5011000110330https://doi. org/10. 13039/5011000110334https://doi. org/10. 13039/5011000110339https://doi. org/10. 13039/501100011033-https://doi. org/10. 13039/501100011033Bhttps://doi. org/10. 13039/501100011033-https://doi. org/10. 13039/501100011033Ihttps://doi. org/10. 13039/5011000110330https://doi. org/10. 13039/5011000110330https://doi. org/10. 13039/501100011033.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1080
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Cancers, Vol. 14 Núm. 2 (1-2 2022) , p. 349, ISSN 2072-6694

DOI: 10.3390/cancers14020349
PMID: 35053511

14 p, 574.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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Articles > Published articles