Look-alike humans identified by facial recognition algorithms show genetic similarities
Joshi, Ricky S. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Rigau, M. (Barcelona Supercomputing Center)
García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Moran, S (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Carrión, P. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Ferrando-Bernal, Manuel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Olalde, I. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Navarro, Arcadi 1969- (Institució Catalana de Recerca i Estudis Avançats)
Fernández-Tena, C. (Herta Security. S.L.)
Aspandi, D. (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions)
Sukno, F.M. (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions)
Binefa i Valls, Xavier (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions)
Valencia, A. (Institució Catalana de Recerca i Estudis Avançats)
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)

Date:	2022
Abstract:	The human face is one of the most visible features of our unique identity as individuals. Interestingly, monozygotic twins share almost identical facial traits and the same DNA sequence but could exhibit differences in other biometrical parameters. The expansion of the world wide web and the possibility to exchange pictures of humans across the planet has increased the number of people identified online as virtual twins or doubles that are not family related. Herein, we have characterized in detail a set of "look-alike" humans, defined by facial recognition algorithms, for their multiomics landscape. We report that these individuals share similar genotypes and differ in their DNA methylation and microbiome landscape. These results not only provide insights about the genetics that determine our face but also might have implications for the establishment of other human anthropometric properties and even personality characteristics.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1080 Agencia Estatal de Investigación RTI2018-094049-B-I00 Agencia Estatal de Investigación TIN2017-90124-P Ministerio de Economía y Competitividad SAF2014-55000
Note:	We thank François Brunelle for providing the look-alike images. We thank CERCA Programme/Generalitat de Catalunya and the Josep Carreras Foundation for institutional support. This work was funded by the governments of Catalonia (2017SGR1080) and Spain (RTI2018-094049-B-I00, SAF2014-55000, and TIN2017-90124-P) and the Cellex Foundation. M.E. conceived and designed the study; R.S.J. M.R. C.A.G.-P. M.C.d.M. D.P. S.M. V.D. P.C. M.F.-B. I.O. C.L.-F. A.N. C.F.-T. D.A. F.M.S. X.B. A.V. and M.E. analyzed multiomics and questionnaire data; R.J. and M.E. wrote the manuscript with contributions and approval from all authors. M.E. is a consultant of Ferrer International and Quimatryx. S.M. is an employee of Ferrer International. C.F.-T. is chief technical officer of Herta Security.
Note:	We thank François Brunelle for providing the look-alike images. We thank CERCA Programme/Generalitat de Catalunya and the Josep Carreras Foundation for institutional support. This work was funded by the governments of Catalonia (2017SGR1080) and Spain (RTI2018-094049-B-I00, SAF2014-55000, and TIN2017-90124-P) and the Cellex Foundation.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Look-alike humans ; Face ; Recognition algorithms ; Genome ; Epigenome ; Microbiome
Published in:	Cell reports, Vol. 40 Núm. 8 (23 2022) , p. 111257, ISSN 2211-1247

DOI: 10.1016/j.celrep.2022.111257

36 p, 6.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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Articles > Published articles