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| Pàgina inicial > Articles > Articles publicats > In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease : |
(Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
| Data: | 2021 |
| Resum: | Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. Methods: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models. Results: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRS: r = 0. 37, p < 0. 001), and this association remained significant after controlling for several potential confounding variables (p = 0. 004). Analysis of individual item scores showed that this association spanned executive and memory domains. No analogue cognition associations were observed for CBF MD. In covariate-controlled models, hippocampal volume was not associated with cognition in PD, but there was a significant association for hippocampal MD (p = 0. 02). Conclusions: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD. |
| Ajuts: | Instituto de Salud Carlos III PI14/01823 Instituto de Salud Carlos III PI16/01575 Instituto de Salud Carlos III PI18/01898 Instituto de Salud Carlos III PI19/01576 Instituto de Salud Carlos III PI20/00613 Instituto de Salud Carlos III CP19/00031 Instituto de Salud Carlos III CD13/00229 Instituto de Salud Carlos III CM18/00142 |
| Nota: | Altres ajuts: Alzheimer Forschung Initiative (AFI International Training Grant to MJG); Fondo Europeo de Desarrollo Regional (FEDER); Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía (CVI-02526, CTS-7685); Consejería de Salud y Bienestar Social de la Junta de Andalucía (PI-0471-2013, PE-0210-2018, PI-0459-2018, PE-0186-2019); Fundación Alicia Koplowitz; Fundación "Curemos el Parkinson" (https://www.curemoselparkinson.org); Universidad de Sevilla (USE-20046-J, USE-18817-A); Programa Acción B-Clínicos-Investigadores (B-0007-2019). |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Nucleus basalis Meynert ; Substantia innominata ; MRI ; DTI ; Diffusion ; Parkinson's disease |
| Publicat a: | Parkinsonism and Related Disorders, Vol. 88 (july 2021) , p. 68-75, ISSN 1873-5126 |
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