Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy
Julià Cano, Antonio (Hospital Universitari Vall d'Hebron)
López Lasanta, María (Vall d'Hebron Institut de Recerca (VHIR))
Blanco-García, F.J. (Complejo Hospitalario Universitario de A Coruña)
Gómez Moruno, Antonio (Vall d'Hebron Institut de Recerca (VHIR))
Haro, Immaculada (Institut de Química Avançada de Catalunya)
Mas, Antonio Juan (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
Erra Duran, Alba (Vall d'Hebron Institut de Recerca (VHIR))
García Vivar, María Luz (Hospital Universitario de Basurto (Bilbao, Biscaia))
Monfort, Jordi (Hospital del Mar (Barcelona, Catalunya))
Sánchez-Fernández, Simón (Hospital General La Mancha Centro (Ciutat Reial))
González, Isidoro (Hospital Universitario de la Princesa (Madrid))
Alperi-López, Mercedes (Hospital Universitario Central de Asturias)
Castellanos-Moreira, Raúl (Fundació Clínic per a la Recerca Biomèdica)
Fernández-Nebro, Antonio (Hospital Regional Universitario de Málaga)
Diaz-Torne, Cesar (Institut d'Investigació Biomèdica Sant Pau)
Palau, Núria (Vall d'Hebron Institut de Recerca (VHIR))
Lastra, Raquel (Vall d'Hebron Institut de Recerca (VHIR))
Lladós, Jordi (Vall d'Hebron Institut de Recerca (VHIR))
Sanmartí, Raimon (Fundació Clínic Recerca Biomèdica)
Marsal, Sara (Vall d'Hebron Institut de Recerca (VHIR))

Data:	2021
Resum:	Background: Blocking of the Tumor Necrosis Factor (TNF) activity is a successful therapeutic approach for 50-60% of rheumatoid arthritis (RA) patients. However, there are yet no biomarkers to stratify patients for anti-TNF therapy. Rheumatoid factor (RF) and anti-cyclic-citrullinated antibodies (anti-CCP) have been evaluated as biomarkers of response but the results have shown limited consistency. Anti-carbamylated protein (anti-CarP) and anti-peptidylarginine deiminase type 4 (anti-PAD4) antibodies have been much less studied. Despite being linked to common immune processes, the interaction between these markers has not been evaluated yet. Our aim was to analyze the interaction between these four antibodies in relation to the response to anti-TNF therapy. Methods: For this objective, a prospective cohort of n = 80 RA patients starting anti-TNF therapy was recruited. Serum determinations at baseline were performed for RF, anti-CCP, anti-CarP and anti-PAD4 antibodies using enzyme-linked immunosorbent assays (ELISA). The clinical response to anti-TNF therapy was determined at week 12 using the change in DAS28 score. Association was performed using multivariate linear regression adjusting for baseline DAS28, sex and age. Results: The interaction between pairs of antibodies was tested by the addition of an interaction term. We found two highly significant antibody interactions associated with treatment response: anti-CarP with anti-PAD4 (p = 0. 0062), and anti-CCP with RF (p = 0. 00068). The latter antibody interaction was replicated in an independent retrospective cohort of RA patients (n = 199, p = 0. 04). Conclusions: The results of this study suggest that antibody interaction effects are important factors in the response to anti-TNF therapy in RA.
Nota:	Altres ajuts: UCB Pharma.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Rheumatoid arthritis ; Treatment response ; Anti-TNF therapy ; Autoantibodies
Publicat a:	BMC musculoskeletal disorders, Vol. 22 Núm. 1 (december 2021) , p. 372, ISSN 1471-2474

DOI: 10.1186/s12891-021-04248-y
PMID: 33882889

7 p, 587.0 KB

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