Obesity and related comorbidities in a large population-based cohort of subjects with type 1 diabetes in Catalonia
Genua, Idoia (Institut d'Investigació Biomèdica Sant Pau)
Franch-Nadal, Josep (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Navas, Elena (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Mata-Cases, Manel (Institut Català de la Salut)
Giménez-Pérez, Gabriel (Universitat Internacional de Catalunya)
Vlacho, Bogdan (Institut d'Investigació Biomèdica Sant Pau)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Goday, Albert (CIBERobn. Instituto de Salud Carlos III)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Introduction: Obesity, an increasing global health problem, can affect people with other disease conditions. The prevalence of obesity in people with type 1 diabetes (T1D) is not well known. The aim of this study was to describe extensively the characteristics and prevalence of different classes of obesity according to BMI (body mass index) categories in a large cohort of patients with T1D. Material and methods: This was a retrospective, cross-sectional study in Catalonia. We reviewed all patients with T1D diagnosis, ≥ 18 years old and with BMI data from the SIDIAP database. Sociodemographic and clinical data, cardiovascular risk factors, laboratory parameters and concomitant medications were collected. Results: A total of 6,068 patients with T1D were analyzed. The prevalence of obesity in the total sample was 18% (13. 8% with class 1 obesity [BMI 30-34. 9 kg/m2]). Patients with obesity had a higher prevalence of other cardiovascular risk factors (i. e. hypertension was 61. 4% vs. 37. 5%; dyslipidemia 63. 6% vs 44%, and chronic kidney disease 38. 4% vs. 24. 4%; p<0. 001 in all cases) and poorer control of them. The higher prevalence was regardless of sex, age and duration of diabetes. The increase in these comorbidities was noticeable from a BMI > 25 kg/m2. Patients with obesity did not have poorer glycemic control. Conclusion: The presence of obesity in people with T1D is frequent and cardiovascular risk factors are more common and more poorly controlled in T1D patients with obesity.
Grants:	Instituto de Salud Carlos III CB15/00071
Note:	Altres ajuts: Lilly S.A.; CIBER-Consorcio Centro de Investigación Biomédica en Red (leading group: CIBERDEM - CB15/00071); Ministerio de Ciencia e Innovación; Unión Europea - European Regional Development Fund.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Obesity ; Type 1 diabetes ; Cardiovascular risk factors ; Metabolic syndrome ; Comorbidities
Published in:	Frontiers in Endocrinology, Vol. 13 (february 2022) , p. 1015614, ISSN 1664-2392

DOI: 10.3389/fendo.2022.1015614
PMID: 36531459

10 p, 460.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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