Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Xifra, Gemma (Hospital Universitari de Girona Doctor Josep Trueta)
Casano-Sancho, Paula (Hospital Sant Joan de Déu (Manresa))
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Biagetti, Betina (Hospital Universitari Vall d'Hebron)
Sesmilo, Gemma (Hospital Universitari Dexeus (Barcelona, Catalunya))
Marcos-Ruiz, Jennifer (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodriguez-Lloveras, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rueda-Pujol, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Aulinas, Anna (Institut d'Investigació Biomèdica Sant Pau)
Blanco, Alberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Hostalot, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Simó-Servat, Andreu (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Muñoz, Fernando (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Rico, Marta (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Ibáñez-Domínguez, Javier (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Cordero Asanza, Esteban (Hospital Universitari Vall d'Hebron)
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau)
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Different medical therapies have been developed for pituitary adenomas. However, Non-Functioning Pituitary Neuroendocrine Tumors (NF-PitNET) have shown little response to them. Furthermore, epithelial-mesenchymal transition (EMT) has been linked to resistance to medical treatment in a significant number of tumors, including pituitary adenomas. We aimed to evaluate the expression of EMT-related markers in 72 NF-PitNET and 16 non-tumoral pituitaries. To further explore the potential usefulness of medical treatment for NF-PitNET we assessed the expression of somatostatin receptors and dopamine-associated genes. We found that SNAI1, SNAI2, Vimentin, KLK10, PEBP1, Ki-67 and SSTR2 were associated with invasive NF-PitNET. Furthermore, we found that the EMT phenomenon was more common in NF-PitNET than in GH-secreting pituitary tumors. Interestingly, PEBP1 was overexpressed in recurrent NF-PitNET, and could predict growth recurrence with 100% sensitivity but only 43% specificity. In parallel with previously reported studies, SSTR3 is highly expressed in our NF-PitNET cohort. However, SSTR3 expression is highly heterogeneous among the different histological variants of NF-PitNET with very low levels in silent corticotroph adenomas. NF-PitNET showed an enhanced EMT phenomenon. SSTR3 targeting could be a good therapeutic candidate in NF-PitNET except for silent corticotroph adenomas, which express very low levels of this receptor. In addition, PEBP1 could be an informative biomarker of tumor regrowth, useful for predictive medicine in NF-PitNET.
Grants:	Ministerio de Economía y Competitividad PMP15/00027 Instituto de Salud Carlos III PMP22/00021
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Dopamine agonists ; Epithelial-mesenchymal transition ; Non-functioning pituitary adenomas ; Somatostatin analogs ; Somatostatin receptor ligands
Published in:	Frontiers in endocrinology, Vol. 14 (march 2023) , ISSN 1664-2392

DOI: 10.3389/fendo.2023.1129213
PMID: 37033229

16 p, 3.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles