Normal Pressure Hydrocephalus Following Cranial Radiation : Identification of Shunting Responders
Cayuela, Nuria (Hospital de Sant Joan Despí Moisès Broggi)
Domínguez-Lizarbe, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Plans, Gerard (Institut d'Investigació Biomèdica de Bellvitge)
Alemany, Montserrat (Institut d'Investigació Biomèdica de Bellvitge)
Sánchez, Juan José (Hospital Universitari de Bellvitge)
Andrés, Begoña (Institut d'Investigació Biomèdica de Bellvitge)
Lucas Martín, Anna (Hospital Universitari de Bellvitge)
Bruna, Jordi (Institut d'Investigació Biomèdica de Bellvitge)
Simó, Marta (Institut d'Investigació Biomèdica de Bellvitge)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	We examined cognitive, brain MRI, and lumbar infusion test (LIT) features to identify predictors of response to ventriculoperitoneal shunting (VPS) in long-term cancer survivors with suspected normal pressure hydrocephalus (NPH) following cranial radiotherapy (RT). Patients who completed cranial RT at least 2 years before with clinically suspected NPH and an Evans' index (EI) ≥ 0. 30 underwent a cognitive and a cerebrospinal fluid (CSF) volumetric (MRI) analysis (n = 36). For those in whom VPS was placed (n = 14), we explored whether adding a CSF volumetric analysis to classical MRI and LIT (Tap Test) features would better identify VPS responders. Nearly 80% exhibited cognitive impairment. The CSF volume at NPH diagnoses was significantly larger in the group of VPS responders (p = 0. 04). The addition of CSF volume to NPH diagnoses increased accuracy to 93%, with a positive and negative predictive value of 91% and 100%, respectively. The addition of a quantitative MRI analysis of CSF volume to classical MRI and LIT NPH criteria, along with a high clinical suspicion of NPH, may help to identify VPS responders, thus improving the clinical management and prognosis of long-term survivors.
Grants:	Instituto de Salud Carlos III PI18/01253
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cancer survivors ; Radiotherapy ; Normal pressure hydrocephalus ; Ventriculoperitoneal shunt ; Volumetric analysis
Published in:	Cancers, Vol. 15 (march 2023) , ISSN 2072-6694

DOI: 10.3390/cancers15071949
PMID: 37046610

12 p, 2.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles