DNA methylation at birth and fine motor ability in childhood : an epigenome-wide association study with replication
Serdarevic, Fadila (Sarajevo School of Science and Technology)
Luo, Mannan (Erasmus University Rotterdam)
Karabegović, Irma (Erasmus University Medical Center)
Binter, Anne-Claire (Instituto de Salud Carlos III)
Alemany, Sílvia (Hospital Universitari Vall d'Hebron)
Mutzel, Ryan (University Medical Centre)
Guxens, Monica (Instituto de Salud Carlos III)
Bustamante, Mariona (Instituto de Salud Carlos III)
Hajdarpasic, Aida (Sarajevo School of Science and Technology)
White, Tonya (Erasmus University Medical Centre)
Felix, Janine F (University Medical Center Rotterdam)
Cecil, Charlotte A.M. (Leiden University Medical Center)
Tiemeier, Henning (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Lower fine motor performance in childhood has been associated with poorer cognitive development and neurodevelopmental conditions such as autism spectrum disorder, yet, biological underpinnings remain unclear. DNA methylation (DNAm), an essential process for healthy neurodevelopment, is a key molecular system of interest. In this study, we conducted the first epigenome-wide association study of neonatal DNAm with childhood fine motor ability and further examined the replicability of epigenetic markers in an independent cohort. The discovery study was embedded in Generation R, a large population-based prospective cohort, including a subsample of 924 ~ 1026 European-ancestry singletons with available data on DNAm in cord blood and fine motor ability at a mean (SD) age of 9. 8 (0. 4) years. Fine motor ability was measured using a finger-tapping test (3 subtests including left-, right-hand and bimanual), one of the most frequently used neuropsychological instruments of fine motor function. The replication study comprised 326 children with a mean (SD) age of 6. 8 (0. 4) years from an independent cohort, the INfancia Medio Ambiente (INMA) study. Four CpG sites at birth were prospectively associated with childhood fine motor ability after genome-wide correction. Of these, one CpG (cg07783800 in GNG4) was replicated in INMA, showing that lower levels of methylation at this site were associated with lower fine motor performance in both cohorts. GNG4 is highly expressed in the brain and has been implicated in cognitive decline. Our findings support a prospective, reproducible association between DNAm at birth and fine motor ability in childhood, pointing to GNG4 methylation at birth as a potential biomarker of fine motor ability.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cognitive function ; Cord blood ; DNA methylation ; EWAS ; Fine motor development
Publicat a:	Epigenetics, Vol. 18 (may 2023) , ISSN 1559-2308

DOI: 10.1080/15592294.2023.2207253
PMID: 37139702

0 p, 1.2 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats