Angiogenic factors for planning fetal surveillance in fetal growth restriction and small-for-gestational-age fetuses : A prospective observational study
Bonacina, Erika (Hospital Universitari Vall d'Hebron)
Mendoza, Manel (Hospital Universitari Vall d'Hebron)
Farràs Llobet, Alba (Hospital Universitari Vall d'Hebron)
García Manau, Pablo (Hospital Universitari Vall d'Hebron)
Serrano, Berta (Hospital Universitari Vall d'Hebron)
Hurtado, Ivan (Hospital Universitari Vall d'Hebron)
Ferrer-Oliveras, Raquel (Hospital Universitari Vall d'Hebron)
Illan, Lidia (Hospital Universitari Vall d'Hebron)
Armengol-Alsina, Mireia (Hospital Universitari Vall d'Hebron)
Carreras Moratonas, Elena (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	The aim of this study was to assess the added value of the soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio for adjusting the periodicity of ultrasound examinations in early-onset fetal growth restriction (FGR) and small for gestational age (SGA). A prospective, observational study. Tertiary referral hospital. One hundred and thirty-four single pregnancies with ultrasonographic estimated fetal weight (EFW) below the 10th centile between 20 +0 and 31 +6 weeks of gestation with antegrade umbilical artery flow. The time from Doppler and sFlt-1/PlGF assessment to delivery was recorded and classified into four ranges: <1, <2, <3 and <4 weeks. Sensitivity (Sn), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of sFlt-1/PlGF values to predict the time to delivery. In the SGA cohort, the NPV calculated for an sFlt-1/PlGF cut-off value of 38 was 100% for delivery before 3 weeks, and 98% for delivery before 4 weeks after diagnosis (95% CI 0. 89-1. 00). In the FGR cohort, the NPV calculated for an sFlt-1/PlGF cut-off value of 38 was 100% for delivery before 2 weeks after diagnosis (95% CI 0. 92-1. 00). By contrast, more than 50% of cases with an sFlt-1/PlGF value of.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Fetal Doppler ; Fetal growth restriction ; Fetal surveillance ; PlGF ; Sflt-1 ; Small for gestational age
Publicat a:	BJOG, Vol. 129 (april 2022) , p. 1870-1877, ISSN 1471-0528

DOI: 10.1111/1471-0528.17151
PMID: 35303394

8 p, 1.1 MB

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