Correction : Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

Fecha:	2023
Resumen:	Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative diseases. Studies of glial fibrillary acidic protein (GFAP), an astrocytic damage marker, may help advance our understanding of different neurodegenerative diseases. In this study, we investigated the diagnostic performance of plasma GFAP (pGFAP), plasma neurofilament light chain (pNfL) and their combination for frontotemporal dementia (FTD) and Alzheimer's disease (AD) and their clinical utility in predicting disease progression. pGFAP and pNfL concentrations were measured in 72 FTD, 56 AD and 83 cognitively normal (CN) participants using the Single Molecule Array technology. Of the 211 participants, 199 underwent cerebrospinal (CSF) analysis and 122 had magnetic resonance imaging. We compared cross-sectional biomarker levels between groups, studied their diagnostic performance and assessed correlation between CSF biomarkers, cognitive performance and cortical thickness. The prognostic performance was investigated, analyzing cognitive decline through group comparisons by tertile. Unlike pNfL, which was increased similarly in both clinical groups, pGFAP was increased in FTD but lower than in AD (all P < 0. 01). Combination of both plasma markers improved the diagnostic performance to discriminate FTD from AD (area under the curve [AUC]: combination 0. 78; pGFAP 0. 7; pNfL 0. 61, all P < 0. 05). In FTD, pGFAP correlated with cognition, CSF and plasma NfL, and cortical thickness (all P < 0. 05). The higher tertile of pGFAP was associated with greater change in MMSE score and poor cognitive outcome during follow-up both in FTD (1. 40 points annually, hazard ratio [HR] 3. 82, P < 0. 005) and in AD (1. 20 points annually, HR 2. 26, P < 0. 005). pGFAP and pNfL levels differ in FTD and AD, and their combination is useful for distinguishing between the two diseases. pGFAP could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD. The online version contains supplementary material available at 10. 1186/s40035-021-00275-w.
Ayudas:	Ministerio de Economía y Competitividad PI14/01126 Instituto de Salud Carlos III PI17/01019 Instituto de Salud Carlos III PI20/01473 Ministerio de Economía y Competitividad PI13/01532 Ministerio de Economía y Competitividad PI16/01825 Instituto de Salud Carlos III PI18/00335 Instituto de Salud Carlos III PI18/00435 Instituto de Salud Carlos III PI17/01896 Instituto de Salud Carlos III AC19/00103
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Frontotemporal dementia ; Glial fibrillary acidic protein ; Neurofilament ; Plasma biomarkers
Publicado en:	Translational Neurodegeneration, Vol. 12 (may 2023) , ISSN 2047-9158

Article original: https://ddd.uab.cat/record/264448?ln=es
Correction: https://ddd.uab.cat/record/282055?ln=es
DOI: 10.1186/s40035-023-00351-3
PMID: 37158972

1 p, 609.6 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
Artículos > Artículos de investigación
Artículos > Artículos publicados

Registro creado el 2023-09-08, última modificación el 2023-10-25

Registros similares

Añadir a la cesta personal
Exportar como Citation, BibTeX, MARC, MARCXML, DC, EDM OpenAire4