Effect of Local Administration of Meglumine Antimoniate and Polyhexamethylene Biguanide Alone or in Combination with a Toll-like Receptor 4 Agonist for the Treatment of Papular Dermatitis due to Leishmania infantum in Dogs
Martínez-Flórez, Icíar (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Guerrero, Maria Jose (Hospital Veterinario Alhaurín el Grande, 29120 Alhaurín el Grande, Spain)
Dalmau, A (AniCura Mediterrani Hospital Veterinari, 43204 Reus, Spain)
Cabré, Maria (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Alcover, M. Magdalena (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient)
Berenguer, Diana (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient)
Good, Liam (University of London. Department of Pathobiology and Population Sciences)
Fisa, Roser (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient)
Riera, Cristina (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient)
Ordeix, Laura (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Solano Gallego, Laia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Data:	2023
Resum:	Papular dermatitis is a cutaneous manifestation of canine Leishmania infantum infection associated with mild disease. Although it is a typical presentation, nowadays, there is still no established treatment. This study evaluated the safety and clinical efficacy of local meglumine antimoniate, locally administered polyhexamethylene biguanide (PHMB) alone or PHMB in combination with a Toll-like receptor 4 agonist (TLR4a) for the treatment of papular dermatitis due to L. infantum and assessed parasitological and immunological markers in this disease. Twenty-eight dogs with papular dermatitis were divided randomly into four different groups; three of them were considered treatment groups: PHMB (n = 5), PHMB + TLR4a (n = 4), and meglumine antimoniate (n = 10)), and the remaining were considered the placebo group (n = 9), which was further subdivided into two sub-groups: diluent (n = 5) and TLR4a (n = 4). Dogs were treated locally every 12 h for four weeks. Compared to placebo, local administration of PHMB (alone or with TLR4a) showed a higher tendency towards resolution of papular dermatitis due to L. infantum infection at day 15 (χ 2 = 5. 78; df = 2, p = 0. 06) and day 30 (χ 2 = 4. ; df = 2, p = 0. 12), while local meglumine antimoniate administration demonstrated the fastest clinical resolution after 15 (χ 2 = 12. 58; df = 2, p = 0. 002) and 30 days post-treatment (χ 2 = 9. 47; df = 2, p = 0. 009). Meglumine antimoniate showed a higher tendency towards resolution at day 30 when compared with PHMB (alone or with TLR4a) (χ 2 = 4. 74; df = 2, p = 0. 09). In conclusion, the local administration of meglumine antimoniate appears to be safe and clinically efficient for the treatment of canine papular dermatitis due to L. infantum infection.
Ajuts:	Ministerio de Economía y Competitividad AGL2015-68477
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Canine ; Cutaneous lesions ; Immunotherapy ; Leishmaniosis ; Local treatment ; Toll-like agonist
Publicat a:	Pathogens, Vol. 12 (june 2023) , ISSN 2076-0817

DOI: 10.3390/pathogens12060821
PMID: 37375511

22 p, 1.4 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats