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| Home > Articles > Published articles > Autosomal dominant polycystic kidney disease in young adults |
(Hospital Universitario Virgen de la Arrixaca) (Institut d'Investigació Biomèdica Sant Pau) (Hospital del Mar (Barcelona, Catalunya)) (Hospital La Mancha-Centro) (Universidad Autónoma de Madrid) (Hospital Clínic i Provincial de Barcelona) (Hospital Universitario Doctor Peset) (Hospital Universitario de Badajoz) (Hospital Universitario Puerta del Ma) (Hospital Universitari de Girona Doctor Josep Trueta) (Hospital Universitari de Girona Doctor Josep Trueta) (Hospital Universitari Vall d'Hebron) (Hospital Universitario Santa Lucía) (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) (Universidad Autónoma de Madrid) (Institut d'Investigació Biomèdica Sant Pau)| Date: | 2022 |
| Abstract: | The clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD) usually appear in adulthood, however pediatric series report a high morbidity. The objective of the study was to analyze the clinical characteristics of ADPKD in young adults. Family history, hypertension, albuminuria, estimated glomerular filtration rate (eGFR) and imaging tests were examined in 346 young adults (18-30 years old) out of 2521 patients in the Spanish ADPKD registry (REPQRAD). A literature review searched for reports on hypertension in series with more than 50 young (age <30 years) ADPKD patients. The mean age of this young adult cohort was 25. 24 (SD 3. 72) years. The mean age at diagnosis of hypertension was 21. 15 (SD 4. 62) years, while in the overall REPQRAD population was aged 37. 6 years. The prevalence of hypertension was 28. 03% and increased with age (18-24 years, 16. 8%; 25-30 years, 36. 8%). Although prevalence was lower in women than in men, the age at onset of hypertension (21 years) was similar in both sexes. Mean eGFR was 108 (SD 21) mL/min/1. 73 m 2, 38. 0% had liver cysts and 3. 45% of those studied had intracranial aneurysms. In multivariate analyses, hematuria episodes and kidney length were independent predictors of hypertension (area under the curve 0. 75). The prevalence of hypertension in 22 pediatric cohorts was 20%-40%, but no literature reports on hypertension in young ADPKD adults were found. Young adults present non-negligible ADPKD-related morbidity. This supports the need for a thorough assessment of young adults at risk of ADPKD that allows early diagnosis and treatment of hypertension. |
| Grants: | Ministerio de Economía y Competitividad RD16/0009/0019 Instituto de Salud Carlos III PI18/00362 Instituto de Salud Carlos III RD21/0005/000 Fundació la Marató de TV3 202036-30 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | ADKPD ; Children ; Glomerular filtration rate ; Hypertension ; Young adults |
| Published in: | Clinical Kidney Journal, Vol. 16 (november 2022) , p. 985-995, ISSN 2048-8513 |
