Predicting Impulse Control Disorders in Parkinson Disease through Incentive Biomarkers
Marín-Lahoz, Juan (Universitat Autònoma de Barcelona. Departament de Medicina)
Martínez-Horta, Saul (Institut d'Investigació Biomèdica Sant Pau)
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau)
Horta, Andrea (Institut d'Investigació Biomèdica Sant Pau)
Aracil-Bolaños, Ignacio (Institut d'Investigació Biomèdica Sant Pau)
Bejr-kasem, Helena (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau)
Campolongo, Antonia (Institut d'Investigació Biomèdica Sant Pau)
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Objective: This study was undertaken to evaluate whether the feedback-related negativity (FRN)-a neurophysiological marker of incentive processing-can be used to predict the development of impulse control disorders (ICDs) in Parkinson disease (PD). Methods: The longitudinal cohort consisted of consecutive nondemented PD patients with no ICD history. We recorded FRN signals while they performed a gambling task. We calculated the mean amplitude difference between losses and gains (FRNdiff) to be used as a predictor of future ICD development. We performed prospective biannual follow-up assessments for 30 months to detect incident ICDs. Finally, we evaluated how basal FRNdiff was associated with posterior development of ICDs using survival models. Results: Between October 7, 2015 and December 16, 2016, we screened 120 patients. Among them, 94 patients performed the gambling and 92 completed the follow-up. Eighteen patients developed ICDs during follow-up, whereas 74 remained free of ICDs. Baseline FRNdiff was greater in patients who developed ICDs than in those who did not (-2. 33μV vs -0. 84μV, p = 0. 001). No other significant baseline differences were found. The FRNdiff was significantly associated with ICD development in the survival models both when not adjusted (hazard ratio [HR] = 0. 73, 95% confidence interval [CI] = 0. 58-0. 91, p = 0. 006) and when controlling for dopamine replacement therapy, sex, and age (HR = 0. 74, 95% CI = 0. 55-0. 97, p = 0. 035). None of the impulsivity measures evaluated was related to ICD development. Interpretation: Reward-processing differences measured by FRN signals precede ICD development in PD. This neurophysiological marker permits identification of patients with high risk of ICD development. ANN NEUROL 2022;92:974-984.
Grants:	Ministerio de Economía y Competitividad PI15/00962 Instituto de Salud Carlos III PI18/01717 Instituto de Salud Carlos III JR20/00007
Note:	Altres ajuts: Fundació la Marató de TV3 (2014/U/477, 20142910); Fondo Europeo de Desarrollo Regional (FEDER); Pla Estratègic de Recerca i Innovació (SLT008/18); CERCA (CEntres de Recerca de Catalunya); CIBERNED (Centro de Investigación Biomédica en Red de enfermedades NEuroDegenerativas).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biomarkers ; Disruptive, Impulse Control, and Conduct Disorders ; Dopamine Agonists ; Humans ; Motivation ; Parkinson Disease ; Prospective Studies
Published in:	Annals of neurology, Vol. 92 Núm. 6 (december 2022) , p. 974-984, ISSN 1531-8249

DOI: 10.1002/ana.26486
PMID: 36054656

11 p, 715.9 KB

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