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Pàgina inicial > Articles > Articles publicats > Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals : |
Data: | 2020 |
Resum: | Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine the association of CAD and oxLDLs-induced microRNAs, and to assess the microRNAs predictive capacity of future CAD events. Human endothelial and vascular smooth muscle cells were treated with oxidized/native low-density lipoproteins, and microRNA expression was analyzed. Differentially expressed and CAD-related miRNAs were examined in serum samples from (1) a case-control study with 476 myocardial infarction (MI) patients and 487 controls, and (2) a case-cohort study with 105 incident CAD cases and 455 randomly-selected cohort participants. MicroRNA expression was analyzed with custom OpenArray plates, log rank tests and Cox regression models. Twenty-one microRNAs, two previously undescribed (hsa-miR-193b-5p and hsa-miR-1229-5p), were up- or down-regulated upon cell treatment with oxLDLs. One of the 21, hsa-miR-122-5p, was also upregulated in MI cases (fold change = 4. 85). Of the 28 CAD-related microRNAs tested, 11 were upregulated in MI cases -1 previously undescribed (hsa-miR-16-5p)-, and 1/11 was also associated with CAD incidence (adjusted hazard ratio = 0. 55 (0. 35-0. 88)) and improved CAD risk reclassification, hsa-miR-143-3p. We identified 2 novel microRNAs modulated by oxLDLs in endothelial cells, 1 novel microRNA upregulated in AMI cases compared to controls, and one circulating microRNA that improved CAD risk classification. |
Ajuts: | Ministerio de Economía y Competitividad CP12/03287 Ministerio de Economía y Competitividad PI14/00449 Ministerio de Ciencia e Innovación PI11/01801 Ministerio de Economía y Competitividad PI15/00064 Ministerio de Economía y Competitividad CB16/11/00229 Ministerio de Economía y Competitividad CB16/11/00246 Ministerio de Economía y Competitividad CB16/11/00403 Ministerio de Sanidad y Consumo CB06/03/0028 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Circulating biomarkers ; Coronary artery disease ; MicroRNAs ; Myocardial infarction ; Oxidized low-density lipoproteins |
Publicat a: | Journal of clinical medicine, Vol. 9 Núm. 5 (may 2020) , p. Article, ISSN 2077-0383 |
14 p, 1.8 MB |