A proposed approach to chronic airway disease (CAD) using therapeutic goals and treatable traits : A look to the future
Pérez de Llano, Luis (University Hospital Lucus Augusti (Lugo, Galícia))
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Golpe, Rafael (University Hospital Lucus Augusti (Lugo, Galícia))
Alvarez Gutiérrez, Francisco Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Cisneros, Carolina (Hospital Universitario La Princesa (Madrid))
Almonacid, Carlos (Hospital Universitario Ramón y Cajal (Madrid))
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València))
González-Barcala, Francisco-Javier (Universidade de Santiago de Compostela)
Ramos-Barbón, David (Institut d'Investigació Biomèdica Sant Pau)
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau)
López-Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
De Torres, Juan Pablo (Queen's University)
Casanova Macario, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
García-Rivero, J. L. (Hospital de Laredo)
Rodriguez Hermosa, Juan Luis (Hospital Clínico San Carlos (Madrid))
Calle Rubio, Myriam (Hospital Clínico San Carlos (Madrid))
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova (València))
Cosio, Borja G (Clínica Quirón-Rotger)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. This has generated the description of new mixed or overlapping disease phenotypes with no clear biological grounds. In this special article, a group of experts provides their perspective and proposes approaching the treatment of chronic airway disease (CAD) through the identification of a series of therapeutic goals (TG) linked to treatable traits (TT) - understood as clinical, physiological, or biological characteristics that are quantifiable using biomarkers. This therapeutic approach needs validating in a clinical trial with the strategy of identification of TG and treatment according to TT for each patient independently of their prior diagnosis.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Airflow obstruction ; Biomarker ; COPD asthma overlap ; Personalized medicine
Published in:	International journal of COPD, Vol. 15 (2020) , p. 2091-2100, ISSN 1178-2005

DOI: 10.2147/COPD.S263430
PMID: 32943862

10 p, 1.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles