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Página principal > Artículos > Artículos publicados > Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals |
Fecha: | 2022 |
Resumen: | Studying the similarities and differences in genomic interactions between species provides fertile grounds for determining the evolutionary dynamics underpinning genome function and speciation. Here, we describe the principles of 3D genome folding in vertebrates and show how lineage-specific patterns of genome reshuffling can result in different chromatin configurations. We (1) identified different patterns of chromosome folding in across vertebrate species (centromere clustering versus chromosomal territories); (2) reconstructed ancestral marsupial and afrotherian genomes analyzing whole-genome sequences of species representative of the major therian phylogroups; (3) detected lineage-specific chromosome rearrangements; and (4) identified the dynamics of the structural properties of genome reshuffling through therian evolution. We present evidence of chromatin configurational changes that result from ancestral inversions and fusions/fissions. We catalog the close interplay between chromatin higher-order organization and therian genome evolution and introduce an interpretative hypothesis that explains how chromatin folding influences evolutionary patterns of genome reshuffling. |
Ayudas: | Agencia Estatal de Investigación CGL2017-83802-P Agencia Estatal de Investigación PID2020-112557GB-I00 Agencia Estatal de Investigación PID2020-115696RB-I00 Ministerio de Economía y Competitividad BES2015-072924 Ministerio de Economía y Competitividad PRE-2018-083257 Ministerio de Ciencia, Innovación y Universidades FPU18/03867 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | 3D genome ; Afrotheria ; Ancestral karyotype ; Compartments ; CP: Molecular biology ; CTCF ; Hi-C ; Inversions ; Mammals ; Marsupials ; TADs |
Publicado en: | Cell reports, Vol. 41, Issue 12 (December 2022) , art. 111839, ISSN 2211-1247 |
25 p, 6.3 MB |