Dietary Fat Patterns and Outcomes in Acute Pancreatitis in Spain
García-Rayado, Guillermo (Instituto de Investigaciones Sanitarias de Aragón (IIS Aragón))
Varela-Moreiras, Gregorio (Universidad CEU San Pablo)
Lanas, Ángel (Instituto de Investigaciones Sanitarias de Aragón (IIS Aragón))
Ferrández, Ángel (Instituto de Investigaciones Sanitarias de Aragón (IIS Aragón))
Balza-Lareu, Nelly (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
Cervera, Juan I. (Hospital Clínico Universitario)
Bodenlle-Bello, María P. (Hospital Meixoeiro)
Argüelles-Arias, Ana M. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Latorre, Patricia (Hospital Universitari Doctor Peset (València))
Udaondo-Cascante, María A. (Hospital Clínico Universitario)
Soria-de-la-Cruz, María J. (Hospital Universitario Puerta del Mar (Cadis, Andalusia))
Lariño-Noia, José (Complejo Hospitalario Universitario de Santiago de Compostela)
García-Figueiras, Roberto (Complejo Hospitalario Universitario de Santiago de Compostela)
Gil-García-Ollauri, Cristina (Hospital Universitario de Cruces (Barakaldo, País Basc))
Ituarte-Uriarte, Ricardo (Hospital Universitario de Cruces (Barakaldo, País Basc))
Rosales-Alexander, Carmen L. (Hospital Universitari de Girona Doctor Josep Trueta)
Soriano, Jordi (Hospital Universitari de Girona Doctor Josep Trueta)
Rodríguez-Peláez, María (Hospital Universitario Central de Asturias)
Mesa-Álvarez, Alicia (Hospital Universitario Central de Asturias)
Oblitas, Elida (Institut d'Investigació Biomèdica Sant Pau)
Menso, Maria M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Bertoletti, Federico (Institut d'Investigació Biomèdica Sant Pau)
Rodríguez-Prada, José I. (Hospital Xeral)
Guzmán-Suárez, Silvia (Hospital Xeral)
Closa, Daniel (Institut d'Investigacions Biomèdiques de Barcelona (IIBB-CSIC))
de-Madaria, Enrique (Hospital General Universitario de Alicante (Alacant, País Valencià))
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Evidence from basic and clinical studies suggests that unsaturated fatty acids (UFAs) might be relevant mediators of the development of complications in acute pancreatitis (AP). The aim of this study was to analyze outcomes in patients with AP from regions in Spain with different patterns of dietary fat intake. A retrospective analysis was performed with data from 1,655 patients with AP from a Spanish prospective cohort study and regional nutritional data from a Spanish cross-sectional study. Nutritional data considered in the study concern the total lipid consumption, detailing total saturated fatty acids, UFAs and monounsaturated fatty acids (MUFAs) consumption derived from regional data and not from the patient prospective cohort. Two multivariable analysis models were used: (1) a model with the Charlson comorbidity index, sex, alcoholic etiology, and recurrent AP; (2) a model that included these variables plus obesity. In multivariable analysis, patients from regions with high UFA intake had a significantly increased frequency of local complications, persistent organ failure (POF), mortality, and moderate-to-severe disease in the model without obesity and a higher frequency of POF in the model with obesity. Patients from regions with high MUFA intake had significantly more local complications and moderate-to-severe disease; this significance remained for moderate-to-severe disease when obesity was added to the model. Differences in dietary fat patterns could be associated with different outcomes in AP, and dietary fat patterns may be a pre-morbid factor that determines the severity of AP. UFAs, and particulary MUFAs, may influence the pathogenesis of the severity of AP.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acute pancreatitis ; Diet ; Fat intake ; Obesity ; Unsaturated fatty acids
Publicat a:	Frontiers in Medicine, Vol. 7 (september 2020) , p. 126, ISSN 2296-858X

DOI: 10.3389/fmed.2020.00126
PMID: 32328495

7 p, 330.2 KB

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