Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia
Falguera, Mireia ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat de Lleida)
Vilanova, Maria Belén (Universitat de Lleida)
Alcubierre, Nuria ![Identificador ORCID](/img/uab/orcid.ico)
(Avantmedic (Lleida))
Granado-Casas, Minerva ![Identificador ORCID](/img/uab/orcid.ico)
(Institut d'Investigació Biomèdica Sant Pau)
Marsal, Josep Ramon ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital Universitari Vall d'Hebron)
Miró, Neus (Institut Català de la Salut)
Cebrian, Cristina (Institut Català de la Salut)
Molló, Àngels (Institut Català de la Salut)
Franch-Nadal, Josep
(Institut Català de la Salut)
Mata-Cases, Manel
(Institut Català de la Salut)
Castelblanco, Esmeralda
(Institut d'Investigació Biomèdica Sant Pau)
Mauricio Puente, Dídac
(Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona
Fecha: |
2020 |
Resumen: |
To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to describe the changes in glycaemic status after 1 year of follow-up in subjects with pre-diabetes. Design Prospective observational cohort study. Setting General population from a semi-rural area. Participants The study included 583 participants without a diagnosis of diabetes recruited between March 2011 and July 2014. The prevalence of undiagnosed diabetes was 20, 3. 4% (95% CI 2. 6 to 4. 2) and that of pre-diabetes was 229, 39. 3% (37. 3 to 41. 3). Among those with pre-diabetes, 18. 3% had isolated impaired fasting plasma glucose (FPG) (FPG: 100 to <126 mg/dL), 58. 1% had isolated impaired glycated haemoglobin (HbA1c) (HbA1c 5. 7 to <6. 5) and 23. 6% fulfilled both criteria. Follow-up data were available for 166 subjects; 41. 6%(37. 8 to 45. 4) returned to normoglycaemia, 57. 6% (57. 8 to 61. 4) persisted in pre-diabetes and 0. 6% (0 to 1. 2) progressed to diabetes. Individuals with pre-diabetes had worse cardiometabolic risk profiles and sociodemographic features than normoglycaemic subjects. In the logistic regression model, variables significantly associated with pre-diabetes were older age (OR; 95% CI) (1. 033; 1. 011 to 1. 056), higher physical activity (0. 546; 0. 360 to 0. 827), body mass index (1. 121; 1. 029 to 1. 222) and a family history of diabetes (1. 543; 1. 025 to 2. 323). The variables significantly associated with glycaemic normalisation were older age (0. 948; 0. 916 to 0. 982) and body mass index (0. 779; 0. 651 to 0. 931). Conclusions Among adults in our region, the estimated prevalence of undiagnosed diabetes was 3. 4% and that of pre-diabetes was 39. 3%. After a 1-year follow-up, a small proportion of subjects (0. 6%) with pre-diabetes progressed to diabetes, while a high proportion (41. 6%) returned to normoglycaemia. Individuals with pre-diabetes who returned to normoglycaemia were younger and had a lower body mass index. |
Derechos: |
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Lengua: |
Anglès |
Documento: |
Article ; recerca ; Versió publicada |
Materia: |
Prediabetes ;
Prediabetes prevalence ;
Undiagnosed diabetes |
Publicado en: |
BMJ open, Vol. 10 Núm. 1 (20 2020) , p. 33332, ISSN 2044-6055 |
DOI: 10.1136/bmjopen-2019-033332
PMID: 31964673
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