Chemical targeting of amyloids
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Date:	2023
Abstract:	Cryo-EM structures of chemical compound bound α-synuclein amyloid fibrils shed light on the mechanism by which small molecules bind to cross-beta-sheet amyloid structures, opening the gateway to rational drug design for targeting pathological amyloid assemblies.
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Molecular neuroscience ; Proteins ; Small molecules
Published in:	Nature chemical biology, Vol. 19, issue 10 (Oct. 2023) , p. 1176-1177, ISSN 1552-4469

DOI: 10.1038/s41589-023-01394-3

Available from: 2024-10-30 Article. Postprint

Available from: 2024-10-30 Figura. Postprint

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles