Psoriasis and mental health workshop report : Exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk
Kleyn, C.Elise (Manchester Academic Health Science Centre)
Talbot, Peter S. (University of Manchester)
Mehta, Nehal N. (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Sampogna, Francesca (IDI-IRCCS)
Bundy, Chris (Cardiff University)
Ashcroft, Darren M. (University of Manchester)
Kimball, Alexa B. (Beth Israel Deaconess Medical Center)
van de Kerkhof, Peter C.M. (International Psoriasis Council)
Griffiths, Christopher E.M. (NIHR Manchester Biomedical Research Centre)
Valenzuela, Fernando (University of Chile and Probity Medical Research)
van der Walt, Joelle M. (International Psoriasis Council)
Aberra, Tsion (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Puig-Verdié, Lluís (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, "Psoriasis and Mental Health", in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro-and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cardiovascular mental health ; Depression ; Neuroinflammation ; Psoriasis ; Sleep
Publicat a:	Acta dermato-venereologica, Vol. 100 Núm. 1 (january 2020) , p. adv00020, ISSN 1651-2057

DOI: 10.2340/00015555-3375
PMID: 31742649

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