Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex : Secondary analysis of the DALI study
Lima, Rodrigo A (University of Graz)
Desoye, G. (Medizinische Universitaet Graz)
Simmons, D. (Addenbrookes Hospital (Cambridge, Regne Unit))
Devlieger, Roland (University Hospitals Leuven (Bèlgica))
Galjaard, S. (University Medical Centre)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Adelantado, Juan M.. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Dunne, F. (National University of Ireland)
Harreiter, J. (Medical University of Vienna)
Kautzky-Willer, A. (Medical University of Vienna)
Damm, P. (University of Copenhagen)
Mathiesen, E.R. (University of Copenhagen)
Jensen, Dorte M (University of Southern Denmark)
Andersen, Lise-Lotte (University of Southern Denmark)
Tanvig, M. (University of Southern Denmark)
Lapolla, A. (Universita Degli Studi di Padova)
Dalfra, Maria Grazia (Università Degli Studi di Padova)
Bertolotto, Alessandra (Azienda Ospedaliero Universitaria - Pisa)
Wender-Ozegowska, E. (Poznan University of Medical Sciences)
Zawiejska, Agnieszka (Poznan University of Medical Sciences)
Hill, D.J. (Recherche en Santé Lawson SA)
Snoek, F. J. (Amsterdam Public Health Research Institute)
Jelsma, Judith G. M (Amsterdam Public Health Research Institute)
van Poppel, M.N.M. (Amsterdam Public Health Research Institute)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	To investigate the importance of time in pregnancy and neonatal sex on the association between maternal metabolic parameters and neonatal sum of skinfolds. This was a longitudinal, secondary analysis of the vitamin D and lifestyle intervention for gestational diabetes mellitus study, conducted in nine European countries during 2012 to 2015. Pregnant women with a pre-pregnancy body mass index (BMI) of ≥29 kg/m were invited to participate. We measured 14 maternal metabolic parameters at three times during pregnancy: <20 weeks, 24 to 28 weeks, and 35 to 37 weeks of gestation. The sum of four skinfolds assessed within 2 days after birth was the measure of neonatal adiposity. In total, 458 mother-infant pairs (50. 2% female infants) were included. Insulin resistance (fasting insulin and HOMA-index of insulin resistance) in early pregnancy was an important predictor for boys' sum of skinfolds, in addition to fasting glucose and maternal adiposity (leptin, BMI and neck circumference) throughout pregnancy. In girls, maternal lipids (triglycerides and fatty acids) in the first half of pregnancy were important predictors of sum of skinfolds, as well as fasting glucose in the second half of pregnancy. Associations between maternal metabolic parameters and neonatal adiposity vary between different periods during pregnancy. This time-dependency is different between sexes, suggesting different growth strategies.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Foetal growth ; Foetal programming ; Maternal health ; Metabolic syndrome ; Neonatal body composition ; Pregnancy
Publicat a:	Pediatric Obesity, Vol. 15 Núm. 7 (january 2020) , p. e12628, ISSN 2047-6310

DOI: 10.1111/ijpo.12628
PMID: 32141687

11 p, 996.5 KB

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