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| Home > Articles > Published articles > High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5 : |
(Institut d'Investigació Sanitària Pere Virgili) (Institut d'Investigació Biomèdica Sant Pau) (Hospital Clínic i Provincial de Barcelona) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (CAP Sant Pere) (Hospital Universitari Vall d'Hebron. Institut de Recerca) (Universitat Rovira i Virgili) (Universitat Rovira i Virgili) (Universitat Rovira i Virgili) (Universitat Rovira i Virgili) (Hospital Clínic i Provincial de Barcelona) (Universitat Rovira i Virgili) (Universitat Rovira i Virgili) (Universitat Rovira i Virgili)| Date: | 2020 |
| Abstract: | The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4 T-cell turnover. We evaluated the circulating baseline and 48-week follow-up concentrations of SDF-1/CXCL12, fractalkine/CX3CL1, MCP-1/CCL2, MIP-α/CCL3, MIP-β/CCL4 and RANTES/CCL5, and we estimated their association with CXCL12, CX3CR1, CCR2, CCL5 and CCR5 single nucleotide polymorphisms (SNPs) to investigate multiple chemokine-chemokine receptor signatures associated with immune dysregulation preceding poor immune recovery. The circulating concentrations and gene expression patterns of SDF-1/CXCL12 (CXCL12 rs1801157) and MCP-1/CCL2 (CCR2 rs1799864_814) were associated with immune recovery status. CCR2 rs1799864_814 and CCR5 rs333_814 (Δ32) determine the baseline plasma RANTES and MIP-α concentrations, respectively, in participants with poor immune response. SDF-1/CXCL12 and MCP-1/CCL2 could be considered prognostic markers of immune failure despite suppressive antiretroviral therapy. The strong linkage disequilibrium (LD) between CCR2 rs1799864_814 and CCR5 rs1800024 indicated that the alleles of each gene are inherited together more often than would be expected by chance. This work was supported by Fondo de Investigacion Sanitaria and SPANISH AIDS Research Network (ISCIII-FEDER); AGAUR and Gilead Fellowship. FV and YMP are supported by grants from the Programa de Intensificación (ISCIII) and Servicio Andaluz de Salud, respectively. JVG,EY and LR are supported by the Instituto de Salud Carlos III (ISCIII). AR is supported by Departament de Salut, Generalitat de Catalunya and by the Instituto de Salud Carlos III (ISCIII). |
| Grants: | Ministerio de Economía y Competitividad PI16/00503 Instituto de Salud Carlos III PI18/01216 Instituto de Salud Carlos III PI19/01337 Instituto de Salud Carlos III PI20/00326 Ministerio de Economía y Competitividad RD12/0017/0005 Ministerio de Economía y Competitividad RD16/0025/0002 Ministerio de Economía y Competitividad RD16/0025/0006 Ministerio de Economía y Competitividad RD16/0025/0019 Ministerio de Economía y Competitividad PT13/0010/0029 Ministerio de Economía y Competitividad PT13/0010/0062 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Chemokine receptors ; Chemokines ; HIV ; Polymorphisms variants ; Poor immune recovery |
| Published in: | EBioMedicine, Vol. 62 (december 2020) , p. 103077, ISSN 2352-3964 |
