Cross-talk between lipoproteins and inflammation : The role of microvesicles
Chiva-Blanch, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)

Date:	2019
Abstract:	Atherothrombosis is the principal underlying cause of cardiovascular disease (CVD). Microvesicles (MV) are small blebs originated by an outward budding at the cell plasma membranes, which are released in normal conditions. However, MV release is increased in pathophysiologic conditions such as CVD. Low density lipoprotein (LDL) and MV contribute to atherothrombosis onset and progression by promoting inflammation and leukocyte recruitment to injured endothelium, as well as by increasing thrombosis and plaque vulnerability. Moreover, (oxidized)LDL induces MV release and vice-versa, perpetuating endothelium injury leading to CVD progression. Therefore, MV and lipoproteins exhibit common features, which should be considered in the interpretation of their respective roles in the pathophysiology of CVD. Understanding the pathways implicated in this process will aid in developing novel therapeutic approaches against atherothrombosis.
Grants:	Ministerio de Economía y Competitividad RD16/0011/0018 Ministerio de Economía y Competitividad CB16/11/00411
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Atherothrombosis ; Cardiovascular disease ; Endothelial cells ; Inflammation ; LDL cholesterol ; Leukocytes ; Lipoproteins ; Microparticles ; Microvesicles ; Platelets
Published in:	Journal of clinical medicine, Vol. 8 Núm. 12 (december 2019) , p. 2059, ISSN 2077-0383

DOI: 10.3390/jcm8122059
PMID: 31771128

12 p, 867.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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