Clinical presentation of individuals with human T-cell leukemia virus type-1 infection in Spain
De Mendoza, Carmen (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Piron, Maria (Banco de Sangre and Tejidos)
Gonzalez, Rocío (Regional Transfusion Center)
Jiménez, Ana (Centro de Hemoterapia y Hemodonación de Castilla y León)
Caballero, Estrella (Hospital Universitari Vall d'Hebron)
Roc, Lourdes (Hospital Universitario Miguel Servet (Saragossa))
Benito, Rafael (Hospital Clínico Universitario Lozano Blesa)
Ramos, José Manuel (Hospital General Universitario de Alicante (Alacant, País Valencià))
Soriano, Vicente (UNIR Health Sciences School)
Rodríguez, Carmen (Centro Sanitario Sandoval)
Vera, M. (Centro Sanitario Sandoval)
Del Romero, Jorge (Centro Sanitario Sandoval)
Marcaida, Goitzane (Hospital General Universitario)
Ocete, M.D. (Hospital General Universitario)
Molina Romero, Israel (Hospital Universitari Vall d'Hebron)
Aguilera, Antonio (Hospital Conxo-CHUS (Santiago))
Rodríguez-Calviño, J.J. (Hospital Conxo-CHUS)
Navarro, D. (Hospital Conxo-CHUS)
Rivero, C. (Hospital Conxo-CHUS)
Vilariño, M.D. (Hospital Conxo-CHUS)
Algarate, S. (Hospital Clínico Univers. Lozano Blesa)
Gil, J. (Hospital Clínico Univers. Lozano Blesa)
Ortiz de Lejarazu, Raúl (Hospital Clínico Universitario)
Rojo, Silvia (Hospital Clínico Universitario)
Eirós, José M. (Hospital Rio Hortega)
San Miguel, A. (Hospital Rio Hortega)
Manzardo, Christian (Hospital Clínic i Provincial de Barcelona)
Miró, José M. (Hospital Clínic i Provincial de Barcelona)
García, Juan (Hospital Cristal-Piñor)
Paz, Irmia (Hospital Cristal-Piñor)
Poveda, Eva (INIBIC-Complejo Hospitalario Universitario)
Calderón, Enrique J. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Escudero, Domingo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Trigo-Daporta, Matilde (Complejo Hospitalario)
Diz, Julio (Complejo Hospitalario)
García-Campello, Marta (Complejo Hospitalario)
Rodríguez-Iglesias, Manuel Antonio (Hospital Universitario de Puerto Real (Cadis, Andalusia))
Hernández-Betancor, Araceli Pascual (Hospital Universitario Insular de Gran Canaria)
Martín, Antonio Manuel (Hospital Universitario Insular de Gran Canaria)
Gimeno Gascon, Adelina (Hospital Universitario)
Gutiérrez, Fernando (Hospital General)
Rodríguez, J.C. (Hospital General)
Sánchez, V. (Hospital General)
Gómez-Hernando, C. (Complejo Hospitalario Virgen de la Salud)
Cilla, G. (Hospital de Donostia (Sant Sebastià, País Basc))
Pérez-Trallero, E. (Hospital de Donostia (Sant Sebastià, País Basc))
López-Aldeguer, J. (Hospital Universitari i Politècnic La Fe (València))
Fernández-Pereira, L. (Hospital San Pedro de Alcántara)
Niubó, Jordi (Ciudad Sanitaria de Bellvitge)
Hernández, M. (Hospital Universitario La Laguna)
López-Lirola, A.M. (Hospital Universitario La Laguna)
Gómez-Sirvent, J.L. (Hospital Universitario La Laguna)
Force, Lluís (Hospital General)
Cifuentes, C. (Hospital Son Llátzer)
Pérez, S. (Hospital do Meixoeiro)
Morano, Luís Enrique (Hospital do Meixoeiro)
Raya, C. (Hospital del Bierzo (Ponferrada, Lleó))
González-Praetorius, A. (Hospital Universitario)
Pérez, J.L. (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Peñaranda Vera, Maria (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Hernáez-Crespo, S. (Hospital de Basurto (Bilbao, Biscaia))
Montejo, Jose Miguel (Hospital de Cruces (Barakaldo, Biscaia))
Martínez-Sapiña, Ana (Hospital Universitario Miguel Servet (Saragossa))
Viciana, Isabel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Cabezas, Teresa (Hospital de Poniente (Almería))
Lozano, Ana Belén (Hospital de Poniente (Almería))
Fernández, J.M. (Hospital de Poniente (Almería))
García-Bermejo, Isabel (Hospital Universitario de Getafe (Madrid))
Gaspar Alonso-Vega, Gabriel (Hospital Universitario de Getafe (Madrid))
García, R. (Hospital Universitario Fundación Jiménez Díaz)
Górgolas Hernandez-Mora, Miguel (Hospital Universitario Fundación Jiménez Díaz)
Vegas, C. (Hospital Universitario Fundación Jiménez Díaz)
Blas, J. (Hospital Universitario Fundación Jiménez Díaz)
Miralles, P. (Hospital General Universitario Gregorio Marañón)
Valeiro, M. (Hospital General Universitario Gregorio Marañón)
Aldamiz, T. (Hospital General Universitario Gregorio Marañón)
Margall, Núria (Institut d'Investigació Biomèdica Sant Pau)
Guardia, C. (ICS)
Do Pico, E. (ICS)
Polo, I. (Complejo Hospitalario Navarra)
Aguinaga, A. (Complejo Hospitalario Navarra)
Ezpeleta, C. (Complejo Hospitalario Navarra)
Sauleda, Silvia (Banco de Sangre and Tejidos)
Torres, P. (Centro de Transfusiones)
González, R. (Centro de Transfusiones)
Blanco, L. (Centro de Hemoterapia y Hemodonación de Castilla y León)
Suárez, A. (Hospital Clínico San Carlos (Madrid))
Rodríguez-Avial, I. (Hospital Clínico San Carlos (Madrid))
Pérez-Rivilla, A. (Hospital 12 de Octubre (Madrid))
Parra, P. (Hospital 12 de Octubre (Madrid))
Fernández, M. (Hospital 12 de Octubre (Madrid))
Fernández-Alonso, Miriam (Clínica Universidad de Navarra)
Treviño, A. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Requena, S. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Benítez-Gutiérrez, L. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Cuervas-Mons, V. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Barreiro, P. (Hospital Universitario La Paz (Madrid))
Corral, O. (UNIR Health Sciences School)
Gomez-Gallego, Felix (UNIR Health Sciences School)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses. A nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation. A total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20-25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72. 5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42. 1%), T-cell lymphoma (n = 19; 33. 3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and late presentation are more frequent in these populations compared to Latin Americans. Given that 23% of new HTLV-1 diagnoses in Spain are symptomatic, underdiagnosis must be common. Although screening in blood banks mostly identifies asymptomatic Latin American carriers, a disproportionately high number of Spaniards and Africans are unveiled too late, that is, they already suffer from classic HTLV-1 illnesses.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adult T-cell leukemia ; Epidemiology ; HTLV-1 ; Myelopathy ; Screening
Published in:	Open Forum Infectious Diseases, Vol. 6 Núm. 2 (january 2019) , ISSN 2328-8957

DOI: 10.1093/ofid/ofz036
PMID: 30815504

4 p, 149.0 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles