Circulating soluble CD36 is similar in type 1 and type 2 diabetes mellitus versus non-diabetic subjects
Castelblanco, Esmeralda (Institut d'Investigació Biomèdica Sant Pau)
Sanjurjo, Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Falguera, Mireia (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Hernández, Marta (Hospital Universitari Arnau de Vilanova)
Fernández-Real Lemos, José Manuel (Hospital Universitari de Girona Doctor Josep Trueta)
Sarrias, Maria-Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 diabetes (T1D) patients, 276 type 2 diabetes (T2D) patients, and 522 non-diabetic control subjects) using an enzyme-linked immunosorbent assay (ELISA). Multinomial and logistic regression models were performed to evaluate associations with sCD36 and its association with diabetes types. There were no significant differences in sCD36 (p = 0. 144) among study groups, neither in head-to-head comparisons: non-diabetic versus T1D subjects (p = 0. 180), non-diabetic versus T2D subjects (p = 0. 583), and T1D versus T2D patients (p = 0. 151). In the multinomial model, lower sCD36 concentrations were associated with older age (p < 0. 001), tobacco exposure (p = 0. 006), T2D (p = 0. 020), and a higher-platelets count (p = 0. 004). However, in logistic regression models of diabetes, sCD36 showed only a weak association with T2D. The current findings show a weak association of circulating sCD36 with type 2 diabetes and no association with T1D.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Scd36 ; Type 1 diabetes mellitus ; Type 2 diabetes mellitus
Published in:	Journal of clinical medicine, Vol. 8 Núm. 5 (may 2019) , p. 710, ISSN 2077-0383

DOI: 10.3390/jcm8050710
PMID: 31109109

14 p, 1.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles