Circulating non-coding RNAs in biomarker-guided cardiovascular therapy : A novel tool for personalized medicine?
Gonzalo Calvo, David de (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Vea, Ángela (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Bär, C. (Hannover Medical School)
Fiedler, J. (Hannover Medical School)
Couch, L.S. (Imperial College London)
Brotons, Carlos (Institut d'Investigació Biomèdica Sant Pau)
Llorente-Cortes, Vicenta (Institut d'Investigació Biomèdica Sant Pau)
Thum, T. (Hannover Medical School)
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Current clinical guidelines emphasize the unmet need for technological innovations to guide physician decision-making and to transit from conventional care to personalized cardiovascular medicine. Biomarker-guided cardiovascular therapy represents an interesting approach to inform tailored treatment selection and monitor ongoing efficacy. However, results from previous publications cast some doubts about the clinical applicability of biomarkers to direct individualized treatment. In recent years, the non-coding human transcriptome has emerged as a new opportunity for the development of novel therapeutic strategies and biomarker discovery. Non-coding RNA (ncRNA) signatures may provide an accurate molecular fingerprint of patient phenotypes and capture levels of information that could complement traditional markers and established clinical variables. Importantly, ncRNAs have been identified in body fluids and their concentrations change with physiology and pathology, thus representing promising non-invasive biomarkers. Previous publications highlight the translational applicability of circulating ncRNAs for diagnosis and prognostic stratification within cardiology. Numerous independent studies have also evaluated the potential of the circulating non-coding transcriptome to predict and monitor response to cardiovascular treatment. However, this field has not been reviewed in detail. Here, we discuss the state-of-the-art research into circulating ncRNAs, specifically microRNAs and long non-coding RNAs, to support clinical decision-making in cardiovascular therapy. Furthermore, we summarize current methodological and conceptual limitations and propose future steps for their incorporation into personalized cardiology. Despite the lack of robust population-based studies and technical barriers, circulating ncRNAs emerge as a promising tool for biomarker-guided therapy.
Grants:	Ministerio de Economía y Competitividad CD14/00109 Ministerio de Economía y Competitividad CB16/11/00403
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biomarker ; Cardiovascular disease ; Long non-coding RNAs ; MicroRNAs ; Non-coding RNAs ; Personalized medicine ; Precision medicine
Published in:	European heart journal, Vol. 40 Núm. 20 (january 2019) , p. 1643-1650, ISSN 1522-9645

DOI: 10.1093/eurheartj/ehy234
PMID: 29688487

10 p, 701.1 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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