Prepulse inhibition deficits in inbred and outbred rats and between-strain differences in startle habituation do not depend on startle reactivity levels
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Río-Álamos, Cristóbal (Austral University of Chile)
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències)
Cañete, Toni (Universitat Autònoma de Barcelona. Institut de Neurociències)
Sánchez-González, Ana (Universitat Autònoma de Barcelona. Institut de Neurociències)
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Data:	2022
Resum:	The acoustic startle response and prepulse inhibition (PPI) of startle are measures related to information processing, which is impaired in schizophrenia. Some studies have provided inconclusive patterns of association between both measures in rodents. We assessed the influence of baseline startle response on PPI in large samples of Roman high-(RHA) and low-avoidance (RLA) rat strains and in genetically heterogeneous stock (HS) rats. Results show that RHAs exhibit a PPI deficit compared to RLA rats, which is present regardless of the startle response levels. HS rats were stratified in two sub-samples according to their high or low PPI (HS-highPPI or HS-lowPPI, respectively) scores, and then they were grouped by their differential baseline startle amplitude (high reactivity -HR- or low reactivity -LR-) within each sub-sample. Differences between high- and low-PPI-stratified HS rats remained regardless of their high or low startle amplitude scores. Thus, the impairments in %PPI found in both RHA and HS-LowPPI rats are present irrespective of the relatively high or low levels of startle amplitude in pulse-alone trials. Another objective of the present study was to evaluate whether habituation to the startling stimulus (i. e. , pulse) depends on the initial baseline startle response. RLA rats habituated to the startling stimulus more effectively than RHAs regardless of their baseline startle responses. Conversely, there were no differences in startle habituation in the HS rats grouped by their extreme scores of baseline startle. Altogether, these findings suggest a deficit in information processing in RHA rats, which along with evidence indicating that this strain displays other attentional/cognitive impairments, strengthens the validity of the RHA strain as a putative model of schizophrenia-relevant features.
Ajuts:	Agencia Estatal de Investigación PSI2017-82257-P Agencia Estatal de Investigación PID2020-114697GB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-01587
Nota:	Altres ajuts: "FONDECYT INICIACIÓN" ref. 11190240
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Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Animal model ; Inbred rats ; Outbred rats ; Prepulse inhibition ; Schizophrenia ; Sensorimotor gating ; Startle habituation ; Startle reactivity
Publicat a:	Behavioural Processes, Vol. 197 (April 2022) , ISSN 1872-8308

DOI: 10.1016/j.beproc.2022.104618

Postprint 34 p, 600.7 KB

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