Safinamide in clinical practice : A Spanish multicenter cohort study
Martí-Andrés, Gloria (Clínica Universidad de Navarra)
Jiménez-Bolaños, Rayco (Hospital Universitario Insular de Gran Canaria)
Arbelo, José Matías (Hospital Universitario Insular de Gran Canaria)
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau)
Duran-Herrera, Carmen (Hospital Universitario de Badajoz)
Valenti-Azcarate, Rafael (Clínica Universidad de Navarra)
Luquin, Maria-Rosario (Clínica Universidad de Navarra)
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Safinamide is an approved drug for the treatment of motor fluctuations of Parkinson's Disease (PD) patients with a potential benefit on non-motor symptoms (NMS). A retrospective multicenter cohort study was conducted, in which the clinical effect of safinamide on both motor and NMS was assessed by the Clinical Global Impression of Change scale. Furthermore, we assessed the appearance of adverse events (AEs) and its effect on dyskinesia, that were also recorded in non-fluctuating PD patients and in those previously treated with rasagiline. We included 213 PD patients who received safinamide in addition to their regular levodopa therapy. Thirty-five withdrew prematurely from safinamide, mainly because of AEs. Out of 178, clinical improvement on motor and NMS was found in 76. 4% and 26. 2%, respectively. A total of 44 reported AEs of mild intensity. We did not find a difference concerning the clinical benefit or AEs when comparing either patients who had or had not been taking Monoamine Oxidase B Inhibitor (MAOB-I) previously or between patients with and without motor complications. Safinamide is an effective and safe add-on to levodopa drug for PD patients. Moreover, safinamide could elicit an additional clinical improvement in PD patients previously treated with other MAOB-I and in non-fluctuating patients with suboptimal motor control.
Ajuts:	Ministerio de Educación, Cultura y Deporte FPU16/02457
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adverse drug event ; Drug-Induced ; Dyskinesia ; Motor complications ; Parkinson's Disease ; Safinamide
Publicat a:	Brain sciences, Vol. 9 Núm. 10 (october 2019) , p. 272, ISSN 2076-3425

DOI: 10.3390/brainsci9100272
PMID: 31614574

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