Multimodal treatment for smoking cessation with varenicline in alcoholic, methadone-maintained, and psychotic patients : A one-year follow-up
Raich, Antònia (Universitat de Barcelona)
Pinet, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Ballbè, Montse
Mondon, Silvia (Hospital Clínic i Provincial de Barcelona)
Tejedor, Rosa (Althaia Xarxa Assistencial Universitària de Manresa)
Arnau, Anna (Althaia Xarxa Assistencial Universitària de Manresa)
Fernández, Esteve (Hospital Universitari de Bellvitge)
Cano, Margarita
Carcolé, Blanca
Fernández, Teresa
Martínez, Àngela
Nieva, Gemma
Roig, Pilar
Serra, Imma
Serrano, Jaume
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	Numerous studies have evaluated the efficacy and safety of varenicline for smoking cessation in smokers in the general population and, to a lesser extent, among the psychiatric population. However, few studies have evaluated varenicline in patients with other addictions. The present study was conducted to assess outcomes of a multimodal treatment for smoking cessation intervention with varenicline in a sample of alcohol and substance use disorders and patients with psychotic disorders. This was a prospective, multicenter study. The patient sample comprised alcoholics in remission, methadone-maintained patients, and patients with psychotic disorders, all of whom wanted to stop smoking. All participants received multimodal treatment for smoking cessation therapy (psychological therapy plus varenicline). Smoking abstinence and changes in the psychopathological state of patients were assessed at predefined time points during a 12-month follow-up. The probability of tobacco abstinence after one year of treatment was computed using Kaplan-Meier life tables. The probability of abstinence at one year was 0. 225 (95% CI: 0. 143-0. 319). By group, the probabilities were as follows: patients with psychotic disorders 0. 254 (95% CI: 0. 118-0. 415); alcoholics 0. 237 (95% CI: 0. 098-0. 409); and methadone-maintained patients 0. 177 (95% CI: 0. 065-0. 335). Patients with previous quit attempts had a higher probability of achieving abstinence at one year (p<0. 01). The results of this study support the use of multimodal treatment with varenicline in patients with alcohol addiction in remission, patients on methadone maintenance, and patients with stable psychotic disorders. Previous smoking cessation attempts were predictive of smoking cessation success in these patients.
Grants:	Ministerio de Economía y Competitividad INT16/00211
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Addicted patients ; Multimodal treatment ; Psychotic ; Varenicline
Published in:	Tobacco Induced Diseases, Vol. 16 Núm. December (december 2018) , p. 58, ISSN 1617-9625

DOI: 10.18332/tid/99541
PMID: 31516455

11 p, 183.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles