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Página principal > Artículos > Artículos publicados > Prognostic utility of serum free light chain ratios and heavy-light chain ratios in multiple myeloma in three PETHEMA/GEM phase III clinical trials |
Fecha: | 2018 |
Resumen: | We investigated the prognostic impact and clinical utility of serum free light chains (sFLC) and serum heavy-light chains (sHLC) in patients with multiple myeloma treated according to the GEM2005MENOS65, GEM2005MAS65, and GEM2010MAS65 PETHEMA/GEM phase III clinical trials. Serum samples collected at diagnosis were retrospectively analyzed for sFLC (n = 623) and sHLC (n = 183). After induction or autologous transplantation, 309 and 89 samples respectively were available for sFLC and sHLC assays. At diagnosis, a highly abnormal (HA) sFLC ratio (sFLCr) (<0. 03 or >32) was not associated with higher risk of progression. After therapy, persistence of involved-sFLC levels >100 mg/L implied worse survival (overall survival [OS], P = 0. 03; progression-free survival [PFS], P = 0. 007). Among patients that achieved a complete response, sFLCr normalization did not necessarily indicate a higher quality response. We conducted sHLC investigations for IgG and IgA MM. Absolute sHLC values were correlated with monoclonal protein levels measured with serum protein electrophoresis. At diagnosis, HA-sHLCrs (<0. 29 or >73) showed a higher risk of progression (P = 0. 006). Additionally, involved-sHLC levels >5 g/L after treatment were associated with shorter survival (OS, P = 0. 001; PFS, P = 0. 018). The HA-sHLCr could have prognostic value at diagnosis; absolute values of involved-sFLC >100 mg/L and involved-sHLC >5 g/L could have prognostic value after treatment. |
Ayudas: | Ministerio de Ciencia e Innovación PS09/01370 Ministerio de Economía y Competitividad PI12/01761 Ministerio de Economía y Competitividad CD13/00340 Ministerio de Economía y Competitividad JR14/00016 Ministerio de Economía y Competitividad RD12/0036/0048 Ministerio de Economía y Competitividad RD12/0036/0058 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Publicado en: | PloS one, Vol. 13 Núm. 9 (september 2018) , p. e0203392, ISSN 1932-6203 |
14 p, 1.7 MB |