Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder
Hernandez-Rubio, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sanvisens, Arantza (Girona Biomedical Research Institute. Clinical Pharmacology Department)
Barbier-Torres, Lucía (Cedars-Sinai Medical Center)
Blanes, Rafael (Hospital Universitari Son Dureta (Palma de Mallorca, Balears))
Miquel, Laia (Universitat de Barcelona)
Torrens, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Rubio, Gabriel (Universidad Complutense de Madrid)
Bolao, Ferran (Universitat de Barcelona)
Zuluaga Cruz, Andrea Paola (Clinical Pharmacology Department)
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodríguez de Fonseca, Fernando (Instituto de Investigación Biomédica de Málaga)
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Fecha:	2023
Descripción:	7 pàg.
Resumen:	INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD. PATIENTS AND METHODS: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission. RESULTS: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11. 2%, higher than that observed for hypocalcemia (9. 3%), hyponatremia (5. 6%), and hypokalemia (2. 8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3. 25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8. 91; 95% CI, 3. 3-23. 9) and eGFR < 60 mL (OR, 5. 2; 95% CI, 1. 0-26. 2) were the only factors associated with hypoMg. CONCLUSIONS: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.
Nota:	Altres ajuts: acords transformatius de la UAB
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Alcohol use disorder ; Electrolyte disturbances ; Magnesium deficiency ; Oxidative stress ; Liver Cirrhosis/complications ; Cross-Sectional Studies ; Humans ; Middle Aged ; Male ; Alcohol Drinking ; Alcoholism/epidemiology ; Adult ; Female ; Magnesium ; SDG 3 - Good Health and Well-being

DOI: 10.1016/j.drugalcdep.2023.109822
PMID: 36893509

7 p, 638.1 KB

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